The predictive value of PTH,Lp-PLA2,and miR-206 for PMI in patients with coronary heart disease after elective PCI
Objective To study the risk factors of perioperative myocardial injury(PMI)in pa-tients with coronary heart disease undergoing selective percutaneous coronary intervention(PCI)and the predic-tive value of serum parathyroid hormone(PTH),lipoprotein associated phospholipase A2(LP-PLA2),and mi-croRNA-206(miRNA-206)for PMI.Methods From June 2019 to December 2022,98 patients with coronary heart disease who underwent selective PCI at Queshan County People's Hospital were chosen as study partici-pants.They were divided into two groups:the NC group(no PMI,n=52)and the PMI group(n=46)based on the presence of PMI.Statistical analysis was conducted to identify the risk factors associated with PMI,and the predictive value of blood PTH,Lp-PLA2,and miR-206 for PMI was observed and analyzed.Results There was a statistically significant difference(P<0.05)between the NC group and the PMI group in terms of age,multiple vessel lesions,number of stents implanted,and total length of stents implanted.Risk factors for PMI af-ter PCI treatment included age over 60 years,number of stents implanted≥2,and total length of stents implant-ed≥35 mm(P<0.05).The levels of PTH and Lp-PLA2 in the NC group was lower than that in the PMI group,while the levels of miR-206 were higher in the NC group compared to the PMI group,with a statistically signifi-cant difference(P<0.05).The results of receiver operating characteristic analysis showed that the AUC values for blood PTH,Lp-PLA2,miR-206,and combined indicators predicting the probability of PMI in patients with coronary heart disease undergoing elective PCI in the perioperative period were 0.703,0.694,0.743,and 0.855,respectively.Conclusion The perioperative incidence of PMI in patients with coronary heart disease undergo-ing elective PCI treatment is associated with patient age,number of stent implantations,and total implantation length.Serum levels of PTH,Lp-PLA2,miR-206 are closely linked to the occurrence of PMI after elective PCI for coronary heart disease,and their combination is highly significant in evaluating the occurrence of PMI.
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