Relationship between miR-146a and miR-23b levels and preoperative clinical staging and prognosis in patients with prostate cancer
Objective To explore the relationship between miR-146a,miR-23b and preoperative clinical staging,prognosis of patients with prostate cancer(PCa).Methods A total of 70 patients with PCa and 70 patients with benign prostatic hyperplasia(BPH)at Fengdu County People's Hospital in Chongqing were enrolled in the PCa group and the BPH group between March 2019 and March 2020.All patients under-went prostate tissue sampling.The expression levels of miR-146a and miR-23b in the prostate were detected,and their correlation with clinicopathological characteristics and the prognosis of PCa patients were analyzed.Results The expression levels of miR-146a and miR-23b in the PCa group were lower than those in the BPH group(P<0.05).The levels of miR-146a and miR-23b decreased with the increase of Gleason score and clinical T staging(P<0.05).The expression levels of miR-146a and miR-23b in PCa patients with lymph node metasta-sis were lower than those without lymph node metastasis(P<0.05).The results of Spearman correlation analysis showed that the expression levels of miR-146a and miR-23b were negatively correlated with clinical staging(r=-0.758,-0.760,P<0.05).By the end of follow-up,the expression levels of miR-146a and miR-23b in PCa pa-tients with a poor prognosis were lower than those with a good prognosis(P<0.05).The AUC of miR-146a com-bined with miR-23b for predicting the prognosis of PCa was greater than that of a single index(P<0.05).Conclusion The levels of miR-146a and miR-23b expression in prostate tissues are low in PCa patients.These levels are correlated with clinical staging and have predictive value for poor prognosis.
NETL
NSTL
万方数据
