Laboratory Characteristics of Neurosyphilis Patients
Objective To retrospectively analyze the laboratory test results of neurosyphilis pa-tients and to explore the risk factors.Methods A total of 188 syphilis patients who were admitted to Beijing Ditan Hospital from May 2020 to February 2023 were enrolled into this study,and they were divided into the neurosyphilis group(124 cases)and the syphilis(non-neurosyphilis)group(64 cases).The gender,age and laboratory test results of cerebrospinal fluid and serum were compared between the two groups.Results The age and proportion of male patients in the neurosyphilis group were higher than those in syphilis group,and the differences were statistically significant(P<0.05);The levels of protein,leukocyte,positive rates of TPPA,TRUST,FTA-ABS IgG,Pan's test in cerebrospinal fluid,and positive rates of FTA-ABS IgM,TRUST titer distribution in serum which in the neurosyphilis group were higher than those in syphilis group,and the differences were statistically significant(P<0.05).Compared with the syphilis group,the NLR was higher and the LMR was lower in the neurosyphilis group,which was mainly manifested in the decrease of lymphocyte count,especially CD4+T lymphocyte,and the differences were statistically significant(Z=2.717,P<0.05).Gender(male vs.female)(OR=2.660,95%CI:1.084～6.527,P=0.033),age(OR=1.058,95%CI:1.023～1.095,P=0.001),cerebrospinal fluid protein(OR=1.047,95%CI:1.010～1.085,P=0.013),cerebrospi-nal fluid leukocyte(OR=1.257,95%CI:1.102～1.434,P=0.001),serum TRUST>1∶8(OR=3.461,95%CI:1.123～10.665,P=0.031)may be independent risk predictors for Neurosyphilis.Conclusion Gender(male),advanced age,the elevated level of cerebrospinal fluid protein and white blood cells,and serum TRUST>1∶8 suggest high risk factors for neurosyphilis.
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