Advances in the regulation of microRNAs in respiratory syncytial virus infection in children
Respiratory syncytial virus(RSV)is the most common pathogen of acute lower respira-tory infections in children and poses a serious health risk.However,its pathogenesis remains unclear,and ef-fective prevention or treatment for RSV is still lacking.RSV is an enveloped single-negative-stranded RNA vi-rus that encodes 11 proteins,which are key factors in inducing airway hyper reactivity(AHR).MicroRNAs(miRNAs)have recently been recognized as regulators of gene expression and play a crucial role in viral infec-tions by modulating inflammatory responses,immune cell function,and host immune responses in airway epi-thelial cells.This paper reviews the research progress on the regulatory role of miRNAs in RSV infection,aim-ing to provide new insights for understanding the pathogenesis,diagnosis,and treatment of RSV.
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