Relationship between responsiveness to dual antiplatelet therapy and CYP2C19 genotypes in patients with coronary heart disease
Objective To analyze the relationship between responsiveness to dual antiplatelet ther-apy and cytochrome P450 2C19(CYP2C19)genotypes in patients with coronary heart disease.Methods 96 patients with coronary heart disease who underwent percutaneous coronary intervention(PCI)at Chizhou Sec-ond People's Hospital from March 2021 to February 2023 were enrolled in this study.All patients received dual antiplatelet therapy after the operation.The patients were divided into a high responsiveness group(n=53)and a low responsiveness group(n=43)based on platelet inhibition rate.CYP2C19 genotypes,general informa-tion,and blood biochemical indicators of the two groups were compared.The relationship between responsive-ness to dual antiplatelet therapy and CYP2C19 genotypes in patients with coronary heart disease was analyzed.Results The proportion of CYP2C19 fast metabolic types in the low responsiveness group was lower than that in the high responsiveness group,while the proportion of intermediate,and slow metabolic types was higher than in the high responsiveness group(P<0.05).The levels of total cholesterol(TC),triglycerides(TG),and low-density lipoprotein(LDL)in the low responsiveness group were higher than those in the high responsiveness group(P<0.05).Logistic regression analysis revealed that CYP2C19 genotypes and high LDL levels were risk factors for resistance to dual antiplatelet therapy in patients with coronary heart disease(P<0.05).Conclusion The responsiveness to dual antiplatelet therapy is closely related to CYP2C19 genotypes in patients with coronary heart disease.CYP2C19 slow metabolic type and high LDL levels are risk factors for resistance to dual antiplatelet therapy in patients.Detecting CYP2C19 genotypes may help guide antiplatelet therapy for coronary heart disease.
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