Effect of endoscopic radiofrequency therapy on reflux esophagitis and its influence on serum G-17,PGⅠ,PGⅡ levels
Objective To explore the efficacy of endoscopic radiofrequency therapy for reflux esophagitis and its effects on serum gastrin-17(G-17),pepsinogen Ⅰ(PGⅠ)and pepsinogen Ⅱ(PGⅡ)levels.Methods 126 patients with reflux esophagitis were admitted to Anyang People's Hospital from November 2021 to December 2022.They were retrospectively selected as the study subjects,and divided into two groups:the drug group(n=48)and the radiofrequency group(n=78)based on their treatment methods.The drug group received esomeprazole,and the radiofrequency group underwent endoscopic radiofrequency treat-ment.The efficacy of the two groups was compared.The disappearance time of clinical symptoms such as pan-tothenic acid,retrosternal burning pain,and eating obstruction was compared between the two groups.Serolog-ical indicators[G-17,PGⅠ,PGⅡ]before and after treatment were compared between the two groups.The quality of life and sleep quality scores were also compared between the two groups post-treatment.Results The total effective rate of the RF group was 89.74%,which was higher than that of the drug group(75.00%),and the difference was statistically significant(χ2=4.837,P<0.05).The disappearance time of pantothenic ac-id,post sternal burning pain,and eating obstruction in the RF group was lower than that in the drug group,and the difference was statistically significant(t=3.083,2.750,2.348,P<0.05).After treatment,G-17 and PGⅡ levels in both groups were lower than before treatment,and the radiofrequency group was lower than the drug group.PGⅠ levels were higher than before treatment,and those in the radiofrequency group were higher than those in the drug group,with statistical significance(t=4.372,2.157,2.449,P<0.05).The score of life quality in the RF group was higher than that in the drug group,and the score of sleep quality was lower than that in the drug group,the difference was statistically significant(t=3.165,2.473,P<0.05).Conclusion En-doscopic radiofrequency therapy for reflux esophagitis has a high therapeutic effect.It can effectively reduce the time for clinical symptoms to disappear,improve serum levels of G-17,PGⅠ,and PGⅡ,enhance the quality of sleep and life.This treatment option holds high clinical application value.
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