Effect of rTMS on changes in serum MMP-9,Ang-Ⅰ and NSE levels in patients with ischemic stroke
Objective To explore the effects of rTMS on the changes in serum matrix metallopro-teinase-9(MMP-9),human angiopoietin-1(Ang-Ⅰ)and neuron-specific enolization(NSE)levels in patients with ischemic stroke.Methods One hundred and twenty-two ischemic stroke patients admitted to Shijia-zhuang People's Hospital from April 2021 to September 2022 were selected for the study.They were divided into three groups:a control group(n=37)receiving conventional rehabilitation therapy,a high-frequency stim-ulation group(n=45,receiving conventional rehabilitation therapy+along with high-frequency rTMS,and a low-frequency stimulation group(n=40),receiving conventional rehabilitation therapy+along with low-fre-quency rTMS.The purpose of this division was to compare motor function and neurological function recovery,changes in serum MMP-9,Ang-I and NSE levels,and neurophysiological indexes such as motor evoked poten-tial(MEP)latency and central motor conduction time(CMCT)among the three groups.Results After treat-ment,the Fugl-Meyer exercise score of the observation group was higher than that of the control group,and the NIHSS score of the observation group was lower than that of the control group,and the difference was sta-tistically significant(P<0.05).There was no statistically significant difference in the Fugl-Meyer motor score and NIHSS score between the high-frequency stimulation group and the low-frequency stimulation group(P>0.05).MEP latency and CMCT in the high-frequency stimulation group and the low-frequency stimulation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in MEP latency and CMCT between the high-frequency stimula-tion group and the low-frequency stimulation group(P>0.05).The levels of MMP-9 and NSE in the high-fre-quency stimulation group and the low-frequency stimulation group were lower than those in the control group.The levels of Ang ⅰ in the high-frequency stimulation group and the low-frequency stimulation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion rTMS can decrease serum levels of MMP-9 and NSE in patients with ischemic stroke and increase the level of ANG-I.This is beneficial for the recovery of motor and neurological functions in patients.
Repeat transcranial magnetic stimulationIschemic strokeMMP-9Ang-ⅠNSE
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