Effects of fiberoptic bronchoscopy sputum aspiration combined with alveolar lavage on respiratory function and levels of serum IL-6,TNF-α and hs-CRP in lung cancer patients with postoperative pulmonary infection
Objective To explore the effects of fiberoptic bronchoscopy(FOB)sputum aspira-tion combined with alveolar lavage on respiratory function and levels of serum interleukin-6(IL-6),tumor ne-crosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)in lung cancer patients with postoper-ative pulmonary infection.Methods A total of 96 patients with lung infections after lung cancer surgery at Zigong First People's Hospital were enrolled between September 2018 and September 2021.Using the random number table method,they were divided into a control group(mechanical ventilation combined with a sputum aspiration tube)and an experimental group(FOB sputum aspiration combined with alveolar lavage on the ba-sis of the control group),with 48 cases in each group.The total response rate after a week of treatment,par-tial pressure of carbon dioxide(PaCO2),partial pressure of oxygen(PaO2),oxygen saturation(SpO2%),po-tential of hydrogen(pH)before and after a week of treatment,work of breathing(WOB),air way resistance(RAW),dynamic compliance(Cdyn),peak airway pressure(PIP),clinical pulmonary infection score(CPIS),levels of inflammatory factors(IL-6,TNF-α,hs-CRP),and the occurrence of adverse reactions dur-ing treatment were compared between the two groups.Results After treatment,the total response rate of the experimental group was higher than that of the control group(χ2=5.031,P<0.05).After treatment,blood gas indexes,respiratory function indexes,and CPIS in the experimental group were better than those in the control group(t=3.032,5.530,2.008,5.136,9.344,8.549,3.681,3.557,7.778,P<0.05).Furthermore,after treat-ment,the levels of serum IL-6,TNF-α and hs-CRP in the experimental group were lower than those in the control group(t=21.327,17.291,16.748,P<0.05).There was no significant difference in the incidence of ad-verse reactions between the two groups during treatment(χ2=0.274,P>0.05).Conclusion FOB with sputum aspiration and alveolar lavage can greatly enhance treatment outcomes,facilitate respiratory function re overy,and effectively suppress inflammation in patients with lung infections following lung cancer surgery,all while maintaining a high level of safety.
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