Correlation between serum D-D,MHR,UA,RDW and left ventricular remodeling,cardiac function in patients with coronary heart disease
Objective To explore the correlation between serum D-dimer(D-D),uric acid(UA),monocyte/high-density lipoprotein cholesterol ratio(MHR),red blood cell distribution width(RDW)and left ventricular remodeling,cardiac function in patients with coronary heart disease(CHD).Methods Patients undergoing coronary angiography at the Second People's Hospital of Wuhu were enrolled in the study between January and November 2022.After obtaining informed consent,their general data was collected.Based on the degree of coronary stenosis,participants were divided into the CHD group(68 cases)and the control group(44 cases).Differences in general data,the levels of biochemical indicators,and left ventricular remodeling indicators between the two groups were analyzed using t-tests and χ2-tests.The correlation between D-D,UA,MHR,RDW,left ventricular remodeling indexes,and cardiac function grading was assessed us-ing Pearson and Spearman correlation analysis.Results D-D,MHR,UA,RDW,left atrial diameter(LAD),left ventricular end-diastolic diameter(LVEDD),interventricular septal thickness at diastole(IVSd),left ventricular posterior wall depth(LVPWd),and left ventricular mass index(LVMI)in the CHD group were significantly higher than those in the control group,while left ventricular ejection fraction(LVEF)was significantly lower in the CHD group compared to the control group,and the differences are statistically significant(P<0.05).The results of Pearson correlation analysis indicated that D-D and RDW were negatively correlated with LVEF.Additionally,D-D positively correlation with LAD,LVEDD,IVSd,LVPWd,and LVMI.MHR showed a positive correlated with LAD,LVEDD,and LVMI,while UA was positively correlat-ed with LAD,LVPWd,and LVMI.RDW was found to be positively correlated with LAD and IVSd(P<0.05).The results of Spearman correlation analysis showed that D-D,MHR,UA and RDW were all positively correlated with cardiac function grading(P<0.05).Conclusion Serum D-D,MHR,UA,and RDW are cor-related with left ventricular remodeling and cardiac function grading.These markers can be used to assist in the diagnosis and evaluation of patients'conditions.
Left ventricular remodelingCoronary heart diseaseCardiac functionMonocyte/high-density lipoprotein cholesterol ratio
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