Influence of ultrasound-guided RISS plane block on serum Cor,SP,PGE2 and IL-6 in patients with thoracoabdominal surgery
Objective To explore the influence of ultrasound-guided rhomboid intercostal and sub-serratus(RISS)plane block on serum Cor,SP,PGE2 and IL-6 in patients undergoing thoracoabdominal sur-gery.Methods 126 patients who underwent thoracoabdominal surgery at the First Hospital of Qinhuangdao from January 2021 to July 2022 were selected and divided into an observation group and a control group using the random coin-tossing method,with 63 cases in each group.Both groups received routine anesthesia induc-tion.Following tracheal intubation,the observation group was received ultrasound-guided RISS plane block,while the control group did not receive nerve block.Postoperative Visual Analogue Scale(VAS)scores,seda-tion Ramsay scores,dosage of anesthesia drugs,perioperative hemodynamic indicators(systolic blood pres-sure,diastolic blood pressure,heart rate),and inflammatory stress indicators[cortisol(Cor),substance P(SP),prostaglandin E2(PGE2),interleukin-6(IL-6)]and occurrence of adverse reactions were compared between the two groups of patients.Results At 2,12,and 24 hours after the end of treatment,the VAS score and Ramsay score in the observation group were significantly lower than those in the control group(P<0.05).During surgery and 24 hours after surgery,the dosage of sufentanil in the observation group was signifi-cantly less than that in the control group(P<0.05).The systolic blood pressure,diastolic blood pressure,and heart rate were lower after intubation than before intubation(P<0.05).At 10 minutes after intubation and 10 minutes after drug withdrawal,the systolic blood pressure,diastolic pressure,and heart rate in the observation group were significantly lower than those in the control group(P<0.05).The levels of Cor,SP,PGE2,and IL-6 in peripheral blood of both groups after surgery were lower than before surgery(P<0.05).The levels of Cor,SP,PGE2,and IL-6 in the observation group were lower than those in the control group at 12 and 24 hours after surgery(P<0.05).The total incidence of postoperative adverse reactions in the observation group was significantly lower compared to the control group(P<0.05).Conclusion The ultrasound-guided RISS plane block has demonstrated effective analgesic and sedative effects.It can help alleviate the stress and inflam-matory responses in patients undergoing thoracoabdominal surgery,while also boasting a high level of safety.
Ultrasound-guidedPlane blockPain indexHeart rateSufentanilThoracoabdomi-nal surgery
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