Correlation between Th1/Th2 balance in peripheral blood and fractional exhaled nitric oxide in children with chronic cough
Objective To analyze the correlation between helper T cell 1(Th1)/helper T cell 2(Th2)balance in peripheral blood and fractional exhaled nitric oxide(FeNO)in children with chronic cough.Methods Children with chronic cough who were admitted to Cangzhou People's Hospital from February 2021 to July 2022 were selected as the study subjects and referred to as the research group(n=194).Healthy children with normal lung function in our hospital during the same period were chosen as the control group(n=100).The levels of Th1,Th2,Th1/Th2 and Th1 cytokines[interferon-γ(IFN-γ),interleukin2(IL-2)]and Th2 cyto-kines[interleukin4(IL-4),interleukin5(IL-5)]in peripheral blood of the two groups were compared.FeNO levels were compared between the two groups.The Pearson correlation coefficient was used to analyze the rela-tionship between Th1/Th2 balance and FeNO in peripheral blood.Results The levels of Th1,Th1/Th2,IFN-γ and IL-2 in the peripheral blood of the study group were lower than those of the control group,with statistical significance(t=15.170,16.347,15.785,15.815,P<0.05).Th2,IL-4 and IL-5 levels in the peripheral blood of the study group were higher than those of the control group,and the differences were statistically significant(t=8.313,16.911,17.518,P<0.05).The FeNO level in the research group was higher than that in the control group,and the difference was statistically significant(t=10.897,P<0.05).Pearson correlation coefficient anal-ysis showed that Th1/Th2,IFN-γ and IL-2 in peripheral blood were negatively correlated with FeNO(P<0.05),while IL-4 and IL-5 were positively correlated with FeNO(P<0.05).Conclusion The elevated FeNO levels in children with chronic cough may be related to an imbalance of Th1/Th2 cells in the peripheral blood.
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