Predictive value of serum E2,25(OH)D3 and urine iodine levels in differentiated thyroid carcinoma
Objective To analyze the predictive value of serum estradiol(E2),25-hydroxyvita-min D3[25(OH)D3]and urine iodine levels in differentiated thyroid carcinoma(DTC).Methods 190 pa-tients with DTC who were admitted to Ya'an People's Hospital from September 2021 to September 2022 and confirmed by histopathology were selected as the malignant group.Additionally,125 patients with benign thy-roid lesions were chosen as the benign group and 100 healthy individuals with normal thyroid morphology were selected as the healthy control group.Serum levels of E2,25(OH)D3 and urine iodine in the three groups were compared.Serum E2,25(OH)D3 and urine iodine levels in DTC patients with different clinical charac-teristics were compared.The predictive value of serum E2,25(OH)D3 and urine iodine levels in DTC was an-alyzed using ROC curves.Results Serum E2 and urine iodine levels decreased sequentially from the malig-nant group,to the benign group and finally to the healthy control group.The differences were statistically sig-nificant(P<0.05).Conversely,the 25(OH)D3 level increased sequentially across these groups.In patients with poorly differentiated carcinomas,moderately differentiated carcinomas,and highly differentiated carcino-mas,serum E2 and urine iodine levels decreased sequentially.Additionally,patients with T3-T4 infiltration depth had higher urine iodine levels compared to those with T1-T2 infiltration depth.Patients with lymph node metastasis also had higher urine iodine levels that those without.On the other hand,serum 25(OH)D3 levels increased sequentially in patients with poorly differentiated carcinomas,moderately differentiated carcinomas,and highly differentiated carcinomas.Serum 25(OH)D3 levels in patients with T3-T4 infiltration depth were lower than those in patients with T1-T2 infiltration depth.Serum 25(OH)D3 levels in patients with lymph node metastasis were lower than those in patients without.The differences were statistically significant(P<0.05).ROC curve analysis showed that the combination of serum E2,25(OH)D3 and urinary iodine had a sensitivity,specificity,and AUC of 94.74%,92.80%and 0.978,respectively,for predicting DTC.These val-ues were higher than those obtained using a single indicator(P<0.05).Conclusion Serum E2,25(OH)D3 and urine iodine levels are related to the occurrence and progression of DTC.The combination of all three fac-tors is more conducive to predicting DTC.
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