Effect of external counterpulsation combined with cardiac rehabilitation in treating chronic heart failure and its influence on mitochondrial markers
Objective To study the effect of external counterpulsation combined with cardiac reha-bilitation in treating chronic heart failure and its influence on mitochondrial markers.Methods From January 2022 to January 2023,86 patients with chronic heart failure were randomly divided into an observation group and a control group.The observation group received conventional anti-heart failure drug treatment along with external counterpulsation combined with cardiac rehabilitation treatment,while the control group only received conventional anti-heart failure treatment.Before and 36 days after treatment,measurements were taken for myocardial Tei index,left ventricular ejection fraction(LVEF),6-minute walking distance(6MWD),Min-nesota Heart Failure Quality of Life Questionnaire(MLHFQ)score,activity of daily living(ADL)score,and serum mitochondrial transcription factor A(TFAM)and mitochondrial coupling factor 6(CF6)levels.Follow-up was conducted to track the incidence of poor prognosis and readmission at 6 months after treatment.Results After treatment,the Tei index,LVEF,6MWD,ADL score and serum TFAM level in the observa-tion group were higher than those in the control group,the differences were statistically significant(t=35.257,4.604,13.003,4.804,8.336,P<0.05),The MLHFQ score and serum CF6 level in the observation group were lower than those in the control group,and the difference was statistically significant(t=12.233,7.967,P<0.05).After 6 months of follow-up,the incidence of poor prognosis and readmission rate in the observation group were lower than those in the control group,with statistically significant difference(χ2=6.515,5.460,P<0.05).Conclusion Extracorporeal counterpulsation,when combined with cardiac rehabilitation improves car-diac function and quality of life in the treatment of chronic heart failure.The improvement of mitochondrial function and regulation of mitochondrial markers are possible molecular mechanisms involved.
Chronic heart failureExternal counterpulsationCardiac rehabilitationCardiac functionMitochondrial function
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