Diagnostic value and correlation analysis of red blood cell distribution width,eosinophils,and B-type natriuretic peptide in peripheral blood of patients with acute exacerbation of chronic obstructive pulmonary disease
Objective To analyze the correlation and diagnostic value of red blood cell distribu-tion width(RDW),eosinophilic granulocyte(EOS)and b-type natriuretic peptide(BNP)in peripheral blood of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A retro-spective analysis was performed on 102 patients with AECOPD admitted to Fuyang Fifth People's Hospital from January 2020 to August 2022 as the AECOPD group.At the same time,49 patients with stable chronic obstructive pulmonary disease(COPD)who received treatment at the hospital during the same period were chosen as the reference group.The levels of RDW,EOS,BNP,and pulmonary function indexes such as FEV1,FEV1%pred,FEV1/FVC,PEF were compared between the two groups.The correlation and diagnostic value of RDW,EOS,and BNP in AECOPD patients were analyzed.Results Compared to the reference group,the levels of RDW,EOS,and BNP in the AECOPD group increased significantly(t=5.890,6.880,6.267,P<0.05).Additionally,the levels of FEV1,FEV1%pred,FEV1/FVC and PEF in the AECOPD group decreased significantly compared to the reference group(t=5.857,7.175,6.022,6.767,P<0.05);Pearson analysis showed that RDW,EOS,and BNP were negatively correlated with FEV1,FEV1%pred,FEV1/FVC and PEF in AECOPD patients(P<0.05).ROC curve analysis demonstrated that the area under the curve(AUC)of RDW,EOS,and BNP in the diagnosis of AECOPD was 0.776,0.803 and 0.777,respectively.The AUC for the combined detection of the three was 0.911(P<0.05).Conclusion RDW,EOS,and BNP are abnormally elevated in patients with AECOPD and are negatively correlated with lung function.The combined detection of these indicators has a good application value in the diagnosis of AECOPD.
Red blood cell distribution widthEosinophilic granulocyteB-type natriuretic pep-tideAcute exacerbation of chronic obstructive pulmonary disease
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