The significance of dynamic detection of PCT and D-D combined with CRP levels in the assessment of sepsis grading and regression
Objective To investigate the significance of dynamic testing of PCT and D-D com-bined with CRP levels in sepsis grading and regression assessment.Methods 112 sepsis patients admitted to the Affiliated Hospital of Chengde Medical College from May 2020 to January 2023 were selected as the obser-vation group.Additionally,105 healthy individuals who underwent physical examinations in the hospital dur-ing the same period were randomly selected as the control group.The 112 sepsis patients were divided into the sepsis group(n=49),the severe sepsis group(n=35)and the septic shock group(n=28)based on the severi-ty of their condition.The survival outcomes of the patients after 28 days were analyzed.The study aimed to compare the levels of PCT,D-D,CRP.Sequential Organ Failure Score(SOFA)and Acute Physiology and Chronic Health Score(APACHEⅡ)between the observation and the control groups,and among patients with different sepsis grades.Additionally,the correlation between PCT,D-D,CRP levels,SOFA score,APACHEⅡ score,and the impact of PCT,D-D,CRP levels,and their combination on the prognostic predictive value of sepsis were analyzed.Results The levels of PCT,D-D,and CRP in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of PCT,D-D,and CRP and the SOFA scores and APACHEⅡ scores of the septic shock group were higher than those of the sepsis group and the severe sepsis group at different time points(at the time of admission,3 days of ad-mission,5 days of admission,7 days of admission),with statistically significant differences(P<0.05).PCT,D-D,and CRP levels and SOFA score and APACHEⅡ score were higher in the severe sepsis group than in the sepsis group,and the difference was statistically significant(P<0.05).According to the survival outcome of the patients after 28 days of follow-up,they were divided into the survival group and the death group.In the survival group,at different time points(at the time of admission,3 days of admission,5 days of admission,and 7 days of admission),PCT,D-D,CRP levels,SOFA score and APACHEⅡ score were low-er than those of the death group,and the difference was statistically significant(P<0.05).The levels of PCT,D-D,and CRP in sepsis patients were positively correlated with SOFA score and APACHEⅡ score(P values<0.05).The ROC curves showed that the AUCs of PCT,D-D,CRP,and the combination of the three for pre-dicting the prognosis of patients with sepsis after 28 days of admission were 0.830,0.7230,0.765,0.934,re-spectively,and the combined three had greater predictive value(P<0.05).Conclusion Dynamic testing of PCT,D-D combined with CRP levels can reflect the severity of the patient's condition and progression,and can be used as a reference indicator for grading sepsis.
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