Serum P53,G-17 and MG7-Ag testing combined with gastroscopic pathology in the diagnosis of gastric cancer and precancerous lesions
Objective To study the effect of serum P53 oncogene(P53),gastrin-17(G-17)and human gastric cancer antigen MG7(MG7-associated glycoprotein,MG7-Ag)detection combined with gastro-scopic pathological examination in the diagnosis of gastric cancer and precancerous lesions.Methods In this study,152 patients with early gastric cancer or precancerous lesions diagnosed by gastroscopy were selected using a retrospective method at the Ninety-eight Sixth Hospital of the Air Force from March 2022 to January 2023.The study included statistical results of pathological diagnoses,a comparison of serum P53,G-17 and MG7-Ag levels between the gastric cancer group and the precancerous lesion group,an analysis of the consis-tency between gastroscopic examination performance and the gold standard of pathological diagnosis,and an assessment of the diagnostic value of serum P53,G-17 and MG7-Ag levels combined with gastroscopic patho-logical examination for precancerous lesions of gastric cancer using ROC curve analysis.Results After a path-ological diagnosis of 152 patients with suspected early gastric cancer and precancerous lesions,it was found that 75 patients(49.35%)had gastric cancer,while 77 patients(50.65%)had precancerous lesions of gastric cancer.Among those with precancerous lesions,36 patients(23.68%)had intestinal epithelialization,30 pa-tients(19.74%)had atrophic gastritis and 11 patients(7.24%)had gastric ulcers.The levels of G-17 and MG7-Ag in the gastric cancer group were higher than those in the precancerous lesion group.Additionally,the num-ber of cases with P53 positive expression was greater in the gastric cancer group compared to the precancerous lesion group,with a statistically significant difference(P<0.05).After a gastroscopic examination of the same 152 patients,it was discovered that 70 patients(46.05%)had gastric cancer,while 82 patients(53.95%)had precancerous gastric cancer.Among those with of precancerous lesions,36 patients(23.68%)had intestinal epithelialization,32 patients(21.05%)had atrophic gastritis and 14 patients(9.21%)had gastric ulcers.The ROC curve analysis revealed that the sensitivity and specificity of the combined detection of gastroscopy+P53+G-17+MG7-Ag for diagnosing precancerous lesions of gastric cancer were 92.55%and 91.18%,respectively.These values were significantly higher than those of the individual test(P<0.05).Conclusion Serum P53,G-17 and MG7-Ag are closely related to the occurrence and development of gastric cancer and precancerous lesions.the accuracy of the above serological tests,when combined with gastroscopic pathological examina-tion,is higher for diagnosing gastric cancer and precancerous lesions.
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