Relationship of AST/ALT and albumin with pathological features and prognosis of TACE in patients with liver cancer
Objective To explore the relationship of aspartate aminotransferase(AST)/alanine aminotransferase(ALT)and albumin with pathological features and prognosis of transarterial chemoemboliza-tion(TACE)in patients with liver cancer.Methods 168 patients with liver cancer who received TACE treat-ment at Linyi Cancer Hospital from August 2018 to August 2022 were selected.Based on their survival status one year after surgery,the patients were divided into two groups:those with a good prognosis(27 cases)and those with a poor prognosis(141 cases).The study aimed to compare the differences in AST/ALT levels and albumin levels among patients who underwent TACE with different pathological features.To compare the path-ological characteristics,AST/ALT levels,and albumin levels of patients with hepatocellular carcinoma after TACE with different prognoses.ROC curve analysis was used to determine the predictive value of the above in-dicators on the prognosis of TACE in patients with liver cancer.Logistic binary regression equations were ap-plied to analyze the influence of AST/ALT and albumin on the prognosis of patients with liver cancer undergo-ing TACE.Results The preoperative AST/ALT levels were higher,while the preoperative albumin levels were lower among patients aged≥60 years old,with Child-Pugh grade B,positive HbsAg,tumor diameter>5 cm,multiple tumors,high tumor stage,and low tumor differentiation(P<0.05).There were statistically sig-nificant differences in age,HbsAg status,tumor diameter,quantity,staging,and differentiation degree be-tween the two groups(P<0.05).The preoperative and postoperative AST/ALT in good prognosis group were lower while the preoperative and postoperative albumin levels were higher than those levels in the poor progno-sis group(P<0.05).ROC results showed that the AUCs of preoperative and postoperative AST/ALT and albu-min independently in predicting the prognosis of TACE in patients with liver cancer were 0.887,0.787,0.854 and 0.580 respectively,and the AUC of combined prediction was 0.914(P<0.05).Logistic regression analysis showed that age≥60 years old,tumor diameter>5 cm,multiple tumors,tumor staging,low tumor differentia-tion,preoperative AST/ALT>1.82,preoperative albumin<33.21 g/L,postoperative AST/ALT>1.83,postop-erative albumin<43.96 g/L were all influencing factors affecting the poor prognosis of TACE in patients with liver cancer(P<0.05).Conclusion AST/ALT and albumin levels vary among liver cancer patients with dif-ferent pathological features,and they can predict the prognosis of TACE treatment.
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