Relationship between miR-221,CAR and cardiac function and prognosis in patients with acute myocardial infarction complicated with heart failure
Objective To investigate the relationship between micrornas 221(miR-221),C-reac-tive protein/albumin ratio(CAR)and cardiac function and prognosis in patients with acute myocardial infarc-tion(AMI)complicated with heart failure(HF).Methods From March 2020 to May 2023,a total of 146 cases of AMI complicated with HF were treated at the first hospital affiliated with Hebei Institute of North.These cases were classified according to the Killip classification into groups Ⅱ(n=66),Ⅲ(n=48),and Ⅳ(n=32).The levels of miR-221 and CAR were compared among the three groups.The correlation between the ex-pression levels of miR-221 and CAR and Killip classification in AMI patients with HF was analyzed using the Spearman method.Patients were then divided into a good prognosis group(n=108)and a poor prognosis group(n=38)based on their prognosis outcomes after a six-month follow-up.Single and multiple logistic regression analyses were conducted to identify the risk factors affecting the prognosis of AMI patients with HF.Receiver operating(ROC)curves were drawn to analyze the predictive value of miR-221 and CAR in patients with AMI complicated with HF.Results The expression levels of miR-221 and CAR in group Ⅱ were lower than those in group Ⅲ and Ⅳ,and the differences were statistically significant(F=30.341,24.273,P<0.05).Spearman analysis showed that the expression levels of miR-221 and CAR were positively correlated with Killip classifica-tion(r=0.413,0.426,P<0.05).Univariate analysis showed that there were significant differences in age,Kil-lip grade,hypertension history,left ventricular ejection fraction(LVEF),miR-221 and CAR expression lev-els between the two groups(χ2=4.897,40.842,7.432,14.128,3.460,P<0.05).Multivariate logistic regres-sion analysis further confirmed that Killip grade Ⅲ to Ⅳ,miR-221 and CAR expression levels were indepen-dent risk factors affecting the prognosis of AMI patients complicated with HF(P<0.05).ROC curve analysis showed that the areas under the detection curves of miR-221,CAR and their combined detection were 0.811,0.794 and 0.869(P<0.05).Conclusion The expression levels of miR-221 and CAR may be related to cardiac function in patients with AMI complicated with HF.The combined detection of Mir-221 and CAR may have a high predictive value for the prognosis of patients.
Microribonucleic acid-221Acute myocardial infarctionHeart failureHeart func-tionC-reactive protein/albumin ratio
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