Correlation between serum P2X7R,NF-κB levels and cognitive dysfunction in patients with obstructive sleep apnea
Objective To investigate the correlation between serum P2X7 receptor(P2X7R)and nuclear factor-κB(NF-κB)levels and cognitive dysfunction in patients with obstructive sleep apnea(OSA).Methods 126 OSA patients admitted to Qinghai Provincial People's Hospital from October 2021 to Decem-ber 2022 were selected for the OSA group.They were divided into a cognitive dysfunction group with a MoCA score<26(n=68)and a normal cognitive function group with a MoCA score≥26(n=58)based on the Mon-treal Cognitive Assessment(MoCA)score.Healthy volunteers who underwent physical examinations during the same period were chosen as the control group(n=105).The levels of serum P2X7R and NF-κB were test-ed,and the influencing factors of cognitive dysfunction in OSA patients were analyzed using a logistic regres-sion model.Additionally,the diagnostic value of each indicator for cognitive dysfunction in OSA patients was assessed using a ROC curve.Results The levels of serum P2X7R and NF-κB in the OSA group were higher than those in the control group,and the differences were statistically significant(t=17.295,7.088,P<0.05).The levels of serum P2X7R and NF-κB in the cognitive dysfunction group were higher than those in the nor-mal cognitive function group,and the difference was statistically significant(t=8.469,8.497,P<0.05).The increased levels of serum P2X7R and NF-κB were identified as risk factors for cognitive dysfunction in OSA patients(P<0.05).Serum P2X7R and NF-κB levels were found to be negatively correlated with MoCA scores in OSA patients(P<0.05).The areas under the curve for serum P2X7R and NF-κB levels in the diagnosis of cognitive dysfunction in OSA patients were 0.862(95%CI:0.800～0.923,P<0.05)and 0.859(95%CI:0.794～0.923,P<0.05).Conclusion The levels of serum P2X7R and NF-κB in OSA patients are increased and correlated with cognitive dysfunction.Serum P2X7R and NF-κB have diagnostic value for identifying OSA patients with cognitive dysfunction.
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