Correlation of circadian blood pressure and peripheral blood ACA changes with BCVA and GC-IPL thickness in patients with NA-AION
Objective To analyze the correlation between circadian blood pressure and peripheral blood anti-cardiolipin antibody(ACA)changes and best corrected visual acuity(BCVA)and retinal ganglion cell-internal plexus layer(GC-IPL)thickness in patients with non-arteritic anterior ischemic optic neuropathy(NA-AION).Methods 96 patients with NA-AION(96 eyes)admitted to Cangzhou People's Hospital from June 2021 to June 2022 were selected as the NA-AION group.Another 40 subjects over 50 years old with no eye disease who had undergone a physical examination at our hospital during the same period were included in the control group.The differences in gender,age,circadian blood pressure changes,peripheral blood ACA levels,BCVA and GC-IPL thickness were compared between the two groups,and the risk factors of NA-AION were analyzed using multivariate logistic regression analysis.Pearson correlation analysis was used to examine the correlation of circadian blood pressure,peripheral blood ACA levels and BMI value with BCVA and GC-IPL thickness.Spearman correlation analysis was applied to analyze the correlation between circadian rhythm of blood pressure and BCVA and GC-IPL thickness in patients with NA-AION.Results The propor-tions of hypertension,BMI≥25 kg/m2,alcoholism,Pittsburgh Sleep Quality Index(PSQI)score>7 points and abnormal circadian rhythm of blood pressure in the NA-AION group were higher than those in the control group.Additionally,the daytime mean systolic blood pressure,nighttime mean systolic blood pressure,dia-stolic blood pressure and peripheral blood ACA level were higher in the NA-AION group compared to the in control group(P<0.05).Multivariate logistic regression analysis showed that hypertension,BMI≥25 kg/m2,alcoholism,PSQI score>7 points,abnormal circadian rhythm of blood pressure,nighttime mean systolic blood pressure and peripheral blood ACA level were independent risk factors for NA-AION(P<0.05).BCVA(LogMAR visual acuity)in the NA-AION group was significantly higher than that in the control group,and GC-IPL thickness was significantly thinner than that in the control group(P<0.05).Correlation analysis indi-cated that the nighttime mean systolic blood pressure,diastolic blood pressure,peripheral blood ACA level and BMI in patients with NA-AION were positively correlated with BCVA(LogMAR visual acuity)(P<0.05),and were negatively correlated with GC-IPL thickness(P<0.05).Circadian rhythm of blood pressure was inversely proportional to BCVA(LogMAR visual acuity)(P<0.05),and a positively proportional to GC-IPL thickness(P<0.05).Conclusion Abnormal circadian rhythm of blood pressure,abnormal expres-sion of peripheral blood ACA and BMI value are related to the pathogenesis of NA-AION.
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