Application of CTA combined with serum MMP-9 and TIMP-1 in the diagnosis of ischemic stroke
Objective To explore the application of CT angiography(CTA)combined with se-rum matrix metalloproteinase 9(MMP-9)and tissue inhibitor of metalloproteinase 1(TIMP-1)in the diagno-sis of ischemic stroke.Methods From May 2021 to May 2022,140 patients with cerebral infarction were ad-mitted to the Department of Neurology at our hospital.They were selected as the study group and had under-gone CTA.Digital subtraction angiography(DSA)was used as the gold standard to analyze the diagnostic val-ue of CTA in ischemic stroke.Additionally,80 healthy individuals who visited the hospital for physical exami-nation during the same period were selected as the control group.Serum MMP-9 and TIMP-1 levels were com-pared between the two groups.Results A total of 463 head and neck vessels were examined in the 140 pa-tients.CTA diagnosed 236 vessels without stenosis,66 with mild stenosis,36 with moderate stenosis,46 with severe stenosis,and 22 with occlusion.Compared with DSA,the sensitivity and specificity of CTA in diagnos-ing vascular stenosis in patients with ischemic stroke were 81.25%and 90.15%.CTA diagnosed 74 cases of mild stenosis,16 cases of moderate stenosis,46 cases of severe stenosis,and 4 cases of occlusion.Compared with DSA,the diagnostic sensitivity and specificity of CTA were 82.50%and 83.33%.In the study group,se-rum MMP-9 and TIMP-1 levels were significantly higher than those in the control group(t=73.668,33.925,P<0.05).As stenosis worsened,serum MMP-9 and TIMP-1 levels increased(F=13298.37,901.001,P<0.05).MMP-9 at 247.14 ng/mL as the critical value,there were 53 positive cases and 87 negative cases.TIMP-1 at 239.21 ng/mL as the critical value resulted in 53 positive cases and 87 negative cases.The sensitivity and specificity of the combined diagnosis were 88.75%and 80.00%.Conclusion CTA combined with serum lev-els of MMP-9 and TIMP-1 can enhance the diagnostic accuracy for ischemic stroke.
Ischemic StrokeCT AngiographySerum Matrix Metalloproteinase 9Tissue Inhibi-tor of Metalloproteinase 1Diagnosis
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