Study on the expression of CCL 28 in serum of patients with acute asthma attacks
Objective To explore the significance of CC chemokine ligand 28(CCL 28)in the serum of patients with acute asthma attacks.Methods Fifty patients with an asthma attack admitted to our hospital from May 2022 to May 2023 were selected as the study subjects.50 patients with asthma in remission who were followed up and reviewed in our outpatient clinic during the same period were chosen as the remis-sion group.A control group of 50 healthy individuals who underwent medical checkups was also selected.The study aimed to compare the differences in CCL28 levels among the three groups to evaluate the diagnostic val-ue of CCL28 levels in identifying acute asthma attacks using ROC curves.Furthermore,the study compared the differences in CCL28 levels and lung function indexes among patients with different degrees of acute asth-ma attack severity.The analysis also included examining the correlation between CCL28 levels,lung function indexes,and the severity of acute asthma exacerbation,as well as the correlation between CCL28 levels and lung function indexes.Results The CCL28 level in acute exacerbation was greater than in remission and the control group,with a statistically significant difference(F=2 515.910,P<0.05).The AUC,sensitivity and specificity of serum CCL28 level for diagnosing asthma in acute exacerbation were analyzed by ROC,result-ing in an AUC of 0.884,sensitivity of 82.0%,and specificity of 88.0%.The CCL28 level was highest in the severe group,followed by the moderate group,and then the mild group,with a statistically significant differ-ence(F=27.104,P<0.05).The PEF,FEV1,and FEV1/FVC ratio were lower in the severe group compared to the moderate and mild groups,with statistically significant difference(F=49.112,58.305,50.403,P<0.05).Person correlation analysis showed that serum CCL28 levels were positively correlated with the severity of acute exacerbation asthma(r=0.731,P<0.05),while PEF,FEV1,and FEV1/FVC ratio were negatively correlated with asthma severity(r=-0.822,-0.843,-0.826,P<0.05).Furthermore,serum CCL28 levels were negatively correlated with PEF,FEV1,and FEV1/FVC ratio(r=-0.847,-0.890,-0.821,P<0.05).Conclusion CCL28 is found in high levels in the serum of patients with acute asthma attacks.It is closely linked to the severity of acute asthma attacks and lung function indicators.
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