Relationship between thyroid function index,serum IL-6,IL-10 and renal function in patients with type 2 diabetic nephropathy
Objective To analyze the relationship between thyroid function index,serum interleu-kin-6(IL-6),interleukin-10(IL-10)and renal function in patients with type 2 diabetes mellitus(T2DM)ne-phropathy.Methods Patients with T2DM nephropathy admitted to Huangshan Shoukang Hospital from April 2021 to August 2023 were retrospectively selected as the T2DM nephropathy group(n=65)and the T2DM pa-tients without nephropathy group(n=65).Serum thyroid function[thyroid stimulating hormone(TSH),free tri-iodothyronine(FT3),free thyroxine(FT4)],IL-6,IL-10 and renal function[serum creatinine(Scr),blood urea nitrogen(BUN),estimated glomerular filtration rate(eGFR)]were compared between the two groups.The Pearson correlation coefficient was used to analyze the correlation between TSH,FT3,FT4,IL-6,IL-10,Scr,BUN,and eGFR in T2DM nephropathy patients.Multivariate logistic regression was used to analyze the influencing factors of the occurrence of T2DM nephropathy,and a ROC curve was drawn to analyze the predic-tive value of TSH,FT3,FT4,IL-6 and IL-10 levels on the occurrence of T2DM nephropathy.Results The levels of TSH,IL-6,Scr,and BUN in the T2DM nephropathy group were higher than those in the T2DM group(t=3.031,4.056,15.106,12.401,P<0.05).FT3,FT4,IL-10,and eGFR levels in the T2DM nephropathy group were lower than those in the T2DM group(t=3.135,3.370,3.908,10.881,P<0.05).Pearson correlation coefficient analysis showed that TSH and IL-6 were positively correlated with Scr and BUN,but negatively corre-lated with eGFR(P<0.05).FT3,FT4,and IL-10 were negatively correlated with Scr and BUN,but positively correlated with eGFR(P<0.05).Multivariate logistic regression analysis showed that age>60 years,disease du-ration>10 years,increased TSH level increased,decreased FT3 level,decreased FT4 level,increased IL-6 level,and decreased IL-10 level were independent risk factors for T2DM nephropathy(P<0.05).ROC curve analysis showed that the levels of TSH,FT3,FT4,IL-6,and IL-10 and the area under the curve(AUC)of combined were 0.832,respectively.Combined detection was superior to single detection(P<0.05).Conclu-sion TSH,FT3,FT4,IL-6,and IL-10 levels are correlated with renal function in T2DM patients,and may serve as additional predictors of T2DM nephropathy.
Type 2 diabetic nephropathyThyroid functionInterleukin 6Interleukin 10
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