The relationship between serum NLRP3,IL-17 expression levels and renal function prognosis in patients with sepsis-associated acute kidney injury
Objective To explore the relationship between serum NOD like receptor heat protein domain associated protein 3(NLRP3)and interleukin-17(IL-17)expression levels and renal function and prog-nosis in patients with sepsis associated acute kidney injury(AKI).Methods 1120 sepsis patients admitted to the Affiliated Hospital of Chengde Medical College from January 2021 to December 2023 were selected as the pure sepsis group,and an additional 102 sepsis related AKI patients were selected as the AKI group.After a con-tinuous follow-up of 28 days,the AKI group was divided into a good prognosis group(n=83)and a poor prog-nosis group(n=19)based on the renal prognosis.Using Pearson correlation analysis to explore the correlation between serum NLRP3,IL-17 levels and renal function related indicators in sepsis associated AKI patients.Ad-ditionally,we sought to evaluate the predictive value of serum NLRP3 and IL-17 on renal prognosis in sepsis as-sociated AKI patients using receiver operating characteristic(ROC)curves.Results The serum levels of NLRP3 and IL-17 in the AKI group were higher than those in the simple sepsis group,and the difference was statistically significant(P<0.05).The serum creatinine(Scr),blood urea nitrogen(BUN),and blood uric acid(UA)in the AKI group were higher than those in the simple sepsis group,and the glomerular filtration rate(eGFR)was lower than that in the simple sepsis group,with statistical significance(P<0.05).Pearson correla-tion analysis showed that serum NLRP3 and IL-17 levels in sepsis associated AKI patients were positively corre-lated with Scr,BUN,UA,and negatively correlated with eGFR(P<0.05).The serum levels of NLRP3 and IL-17 in the group with poor prognosis were higher than those in the group with good prognosis,and the differ-ence was statistically significant(P<0.05).The area under the curve(AUC)of serum NLRP3,IL-17,and their combined prediction of renal prognosis in sepsis associated AKI patients were 0.859,0.770,and 0.906,respec-tively.Conclusion The elevated levels of serum NLRP3 and IL-17 are significantly correlated with renal func-tion in sepsis associated AKI patients.These two indicators are expected to serve as potential biomarkers for pre-dicting renal prognosis in patients.
SepsisAcute kidney injuryNOD-like receptor-associated protein 3Interleukin-17
NETL
NSTL
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