Effect of microdynamic negative pressure drainage on wound healing and LDH,CK and CK-MB levels in burn patients
Objective To analyze the effect of microdynamic negative pressure drainage on wound healing and levels of lactate dehydrogenase(LDH),creatine kinase(CK)and creatine kinase-MB(CK-MB)in burn patients.Methods A retrospective,single-center analysis was performed on 137 burn patients admitted to the 99th Hospital and Southeast Hospital Affiliated to Xiamen University from May 2022 to January 2023.After applying inclusion and exclusion criteria,36 patients were excluded,leaving 101 patients for the study.These patients were divided into two groups:50 cases in the control group(treated with traditional dressing changes)and 51 cases in the observation group(treated with microdynamic negative-pressure drainage)based on differ-ent treatment protocols.The clinical outcomes,wound healing,cardiac enzyme profile levels and the occur-rence of postoperative infections were compared between the two groups.Results The total effective rate of the observation group(96.09%)was higher than that of the control group(84.00%),and the difference was sta-tistically significant(P<0.05).Wound pain level was reduced in both groups after 3 weeks of treatment and was lower in the observation group than in the control group,with a statistically significant difference(P<0.05).Wound cleaning time,granulation tissue growth time,and wound healing time of the observation group were shorter than those of the control group,and the difference was statistically significant(P<0.05).After 3 weeks of treatment,the levels of LDH,CK-MB,and CK were decreased in both groups,and they were all lower in the observation group than in the control group,with statistically significant differences(P<0.05).The total in-cidence of postoperative infections in the observation group(5.88%)was lower than that in the control group(20.00%),with statistically significant differences(P<0.05).Conclusion The clinical efficacy of applying microdynamic negative pressure drainage to treat burn patients is high.This treatment helps with wound heal-ing,improves cardiac function,and effectively reduces the incidence of infection.
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