Changes of serum VEGF,MIP-1α and CD40 levels in patients with HICH and relationship with prognosis
Objective To explore the changes of serum vascular endothelial growth factor(VEGF),macrophage inflammatory protein-1α(MIP-1α)and CD40 levels in patients with hypertensive intra-cerebral hemorrhage(HICH)and their relationship with prognosis.Methods The clinical data of 208 patients with HICH and 208 patients with non-HICH who were admitted to the Department of Neurosurgery at Dazhou Integrated TCW&Western Medicine Hospital were selected from January 2020 to January 2023.The patients were divided into the HICH group and the control group,respectively.The differences in serum VEGF,MIP-1α and CD40 levels were compared between the groups.The diagnostic efficiency of serum VEGF,MIP-1α and CD40 levels at admission for patients with HICH was analyzed using receiver operating characteristic curve(ROC).The Glasgow Outcome Scale(GOS)score of patients in the HICH group was recorded.Patients were further divided into a poor prognosis group(GOS≤3 points,n=89)and a good prognosis group(GOS>3 points,n=119),The relationship between serum VEGF,MIP-1α and CD40 levels and GOS score at admission was compared between the two subgroups.Pearson correlation coefficient was used to analyze the correlation be-tween serum VEGF,MIP-1α and CD40 levels at admission and GOS score in patients with HICH.Results The levels of serum VEGF,MIP-1α,and CD40 at admission in the HICH group were significantly higher than those in the control group(P<0.05).ROC analysis showed that the areas under the ROC curves(AUC)of se-rum VEGF,MIP-1α,CD40,and the combination of the three indicators were 0.828,0.874,0.843 and 0.930,respectively.The cut-off values were 356.73 pg/mL,350.81 ng/mL and 420.60 pg/mL.The sensitivities were 66.35%,66.83%,60.01%and 86.06%,and the specificities were 88.94%,93.27%,91.35%and 81.58%,re-spectively(P<0.05).According to the prognosis evaluation criteria,89 patients in the HICH group had a poor prognosis and 119 patients had a good prognosis.Serum levels of VEGF,MIP-1α,and CD40 were significantly higher in the poor prognosis group than those in the good prognosis group(P<0.05).Pearson correlation coeffi-cient analysis revealed that a negative correlation between serum VEGF,MIP-1α,and CD40 levels at admis-sion and the GOS score in patients with HICH.Conclusion Serum VEGF,MIP-1α,and CD40 are highly ex-pressed in HICH patients and can impact patient prognosis.These markers can serve as early clinical auxiliary in-dicators,offering more precise guidance for the treatment and rehabilitation of HICH patients.
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