Relationship between CA125,CYFRA21-1,AFR levels and prognosis of advanced non-small cell lung cancer treated with chemotherapy
Objective To investigate the relationship between glycochain antigen 125(CA125),cytokeratin-19 fragment(CYFRA21-1),albumin-to-fibrinogen ratio(AFR)and prognosis of advanced non-small cell lung cancer.Methods A total of 102 patients with advanced non-small cell lung cancer admitted to the Medical Oncology Department of Suixi County Hospital from June 2019 to June 2023 were selected as the experimental group,and 67 patients with benign lung lesions in Suixi County hospital during the same period were selected as the control group.The levels of CA125,CYFRA21-1 and AFR were compared between the two groups.The experimental group was divided into a response group of 66 cases and a non-response group of 36 cases based on the efficacy criteria of solid tumors after 3 months of chemotherapy follow-up.The pathologi-cal characteristics,CA125,CYFRA21-1 and AFR levels of the two groups were compared.Multi-factor logis-tics regression and ROC curve analysis were used to analyze the relationship and predictive value of CA125,CYFRA21-1,AFR and chemotherapy prognosis of advanced non-small cell lung cancer.Results AFR level in the experimental group was significantly lower than that in the control group,the difference was statistically sig-nificant(t=10.365,P<0.05),CA125 and CYFRA21-1 were higher than that in the control group,the differ-ence was statistically significant(t=20.063,23.479,P<0.05).The proportion of patients with maximum tumor diameter,TNM stage,histological grade and lymph node metastasis in the remission group was higher than that in the unmitigated group,with statistical significance(x2=4.0196,8.302,7.312,4.408,P<0.05),and CA125 and CYFRA21-1 were higher than those in the remission group.The difference was statistically significant(t=7.022,6.016,P<0.05),and the AFR levels were lower than those in the unmitigated group,the difference was statistically significant(t=5.347,P<0.05).Tumor maximum diameter,histological grade,TNM stage,CA125,CYFRA21-1 and AFR were all risk factors for the prognosis of advanced NSCLC after chemotherapy(P<0.05).The combined prognostic value of CA125,CYFRA21-1 and AFR was found to be higher than that of single detection(AUC=0.985,P<0.05).Conclusion CA125,CYFRA21-1,and AFR are all risk factors that impact the prognosis of advanced non-small cell lung cancer chemotherapy.They are closely related to the prog-nosis of advanced non-small cell lung cancer chemotherapy.The combined prediction of CA125,CYFRA21-1,and AFR serves as a strong predictor.
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