Effect of minimally invasive small-incision common pedicle screw fixation therapy on serum CK,HMGB-1 and TNF-α levels in patients with thoracolumbar spine fractures
Objective To investigate the effects of minimally invasive small incision common pedicle screw fixation on serum creatine kinase(CK),high mobility group protein-1(HMGB-1)and tumor ne-crosis factor-α(TNF-α)levels in patients with thoracolumbar spine fractures.TNF-α)levels.Methods Thora-columbar spine fracture patients admitted to Success Hospital of Xiamen University from February 2022 to Feb-ruary 2023 were retrospectively screened.After careful evaluation,144 patients were finally selected,20 cases were excluded,and 124 cases were finally included.The group was divided into a control group(n=60,inci-sion pedicle screw internal fixation treatment)and an experimental group(n=64,minimally invasive small-inci-sion plain pedicle screw fixation treatment)based on the surgical protocol.A comparison of perioperative indi-ces,changes in inflammatory factors[CK,HMGB-1 and TNF-α]before and after treatment,Oswestry dys-function index questionnaire(ODI),Visual Analogue Scale(VAS)scores and postoperative complications were compared between the two groups,VAS scores and postoperative complications.Results Compared to the control group,the experimental group had shorter total operation time,fluoroscopy time,intraoperative hemorrhage,postoperative hospital days and fracture healing time,and less intraoperative hemorrhage,with statistically significant differences(P<0.05).After 1 day and 3 days of treatment,the levels of CK,HMGB-1,and TNF-α increased significantly in both groups,and decreased in 7 days of treatment,and the levels of these in-dicators in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.05).Six months after treatment,the ODI scores and VAS scores of both groups were signifi-cantly reduced,and the above scores of the experimental group were lower than those of the control group,and the difference was statistically significant(P<0.05).The complication rate was lower in the test group(3.12%)compared to the control group(15.00%),and the difference was statistically significant(P<0.05).Conclusion Minimally invasive small-incision common pedicle screw fixation therapy significantly reduces CK,HMGB-1,and TNF-α levels in patients with thoracolumbar spine fractures and promotes faster postoperative recovery.
Minimally invasive small incision common pedicle screw fixationThoracolumbar fractureCKHMGB-1TNF-α
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