Effects of nebulization of budesonide,terbutaline and ipratropium bromide on children with asthma
Objective To study the effects of budesonide combined with terbutaline and ipratro-pium bromide nebulized inhalation on immune function and lung function in children with asthma.Methods 120 children with asthma admitted to Pediatrics of Pengzhou People's Hospital from January 2018 to December 2020 were selected.They were divide into two groups:an observation group and a control group with 60 cases each based on the random number table.The control group received budesonide+terbutaline nebulized inhala-tion treatment,while the observation group was treated with ipratropium bromide nebulized inhalation on the ba-sis of the control group,and the treatment was continuous for 7 days.Lung function indexes of both groups were observed before and after treatment:forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),maximum expiratory flow(PEF),serum immunoglobulin M(IgM),serum immunoglobulin G(iIgG),serum immunoglobulin A(IgA),eosinophils(EOS)and eosinophil cationic protein(ECP)levels in sputum and serum,statistics of asthma disappeared,cough disappeared,wheezing disappeared and hospitaliza-tion post-treatment were recorded.A 6-month follow-up survey(as of June 2021)was carried out,and the child-hood asthma control test scale(C-ACT)was used to monitor disease control.Results After treatment,the FVC,FEV1 and PEF of the observation group were all higher than those of the control group,the difference was statistically significant(P<0.05),and the levels of IgM,IgG and IgA in the observation group were higher than those of the control group after treatment,the difference was statistically significant(P<0.05).Sputum in-duction in the observation group after treatment showed lower contents of EOS and ECP in both the liquid and serum compared to the control group,the difference was statistically significant(P<0.05).After treatment,the observation group experienced disappearance of asthma,cough,wheezing,as well as a shorter hospital stay compared to the control group,and the difference was statistically significant(P<0.05).The observation group also demonstrated better asthma control during the 3-month follow-up period compared to the control group,and the difference was statistically significant(P<0.05).During the 6-month follow-up period,the asthma control situation was similar between the two groups,with not statistically significant difference(P>0.05).Conclusion The use of budesonide combined with terbutaline and ipratropium bromide,in nebulized inhala-tion therapy for children with asthma can effectively enhance the children's lung function,serum immunoglobu-lin levels and reduce airway inflammation.This,in turn,can shorten the time needed for clinical symptom relief and improve disease control to some extent.