Correlation between LP-PLA2,HCY,D-D and the risk of acute myocardial infarction in young age groups
Objective To analyze the correlation between LP-PLA2,HCY,D-D and the risk of AMI in young age group.Methods A total of 312 patients with stable coronary heart disease treated at Zheng-zhou University Hospital and The First Affiliated Hospital of Zhengzhou University were enrolled between Janu-ary 2020 and January 2023.According to presence or absence of AMI onset within 6 months,they were divided into the AMI group(n=86)and the non-AMI group(n=226).At admission and 1 month after admission,the level of Hcy was detected using the enzymatic cycling method,LP-PLA2 was detected using dry fluorescence immunoassay,and D-D levels were measured using latex-enhanced immune transmission turbidity.The risk fac-tors for AMI onset in the young age group were analyzed busing a logistics regression model,and the correla-tion between LP-PLA2,HCY,D-D levels and AMI onset was analyzed using Spearman correlation analysis.Results There were significant differences in gender,smoking history and hyperlipidemia history between the AMI group and the non-AMI group(P<0.05),but there was no significant difference in age,hypertension his-tory,drinking history,family history,diabetes history or NYHA grading(P>0.05).At admission and 1 month after admission,levels of serum LP-PLA2,Hcy and D-D in the AMI group were significantly higher than those in the non-AMI group(at admission:t=7.291,4.672,6.696,P<0.001;1 month later:t=16.783,8.974,11.360,P<0.001).LP-PLA2 at admission>175 μg/L,Hcy at admission>15 μmol/L,D-D at admission>0.5 mg/L,LP-PLA2 at 1 month after admission>175 μg/L,Hcy at 1 month after admission>15 μmol/L and D-D at 1 month after admission>0.5 mg/L were independent risk factors of AMI onset in the young age group(P<0.05).The onset risk of AMI was positively correlated with levels of serum LP-PLA2,HCY and D-D at admission(r=0.826,0.775,0.724,P<0.05).Conclusion The levels of LP-PLA2,Hcy,and D-D at admission are corre-lated with the onset in AMI patients with coronary heart disease,and the three indicators are independent risk factors for AMI onset in younger age groups.
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