Predictive value of serum AQP combined with CT cerebral perfusion imaging parameters on short-term prognosis of acute ischemic stroke patients
Objective To investigate the predictive value of CT cerebral perfusion imaging param-eters combined with serum aquaporin(AQP)on short-term prognosis of patients with acute ischemic stroke(AIS)after thrombolysis.Methods AIS patients who underwent intravenous thrombolysis from September 2021 to December 2023 were selected.CT cerebral perfusion imaging was performed before thrombolysis and the parameters mean time to transit(MTT)and time to peak(TTP)were calculated.Serum samples were col-lected and the levels of AQP1,AQP4 and AQP9 were detected.Based on the National Institutes of Health Stroke Scale(NIHSS)score at admission,the patients were divided into three groups:the mild group(NIHSS score≤4 points),the moderate group(NIHSS score 5-19 points),and the severe group(NIHSS score 20-25 points).According to the modified Rankin Scale(mRS)score on the 90th day after thrombolytic therapy,the patients were divided into a good prognosis group(mRS Score 0-2)and a poor prognosis group(mRS Score 3-5).The differences in MTT,TTP and serum levels of AQP1,AQP4 and AQP9 among all groups were com-pared.Logistic multivariate regression was used to analyze the influencing factors of poor prognosis,and a ROC curve was used to analyze the predictive value of each influencing factor for poor prognosis.Results The com-parison of MTT,TTP and serum levels of AQP1,AQP4,and AQP9 in AIS patients with different degrees of nerve injury was as follows:mild group<moderate group<severe group,the differences were statistically sig-nificant(P<0.05).The age,NIHSS score at admission,maximum lesion diameter,MTT,TTP,serum AQP1,AQP4 and AQP9 levels of AIS patients in the poor prognosis group were higher than those in the good prognosis group,with statistical significance(P<0.05).MTT,TTP,AQP1,AQP4,and NIHSS score at admission were the influencing factors for the short-term prognosis of AIS patients(P<0.05).Each influencing factor had predictive value for the short-term prognosis of AIS patients,with a sensitivity and specificity of the combined prediction at 84.31%and 92.86%,respectively.Conclusion CT cerebral perfusion imaging parameters MTT and TTP com-bined with serum AQP1 and AQP4 levels can predict the short-term prognosis of AIS patients after thrombolysis.
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