Relationship between serum Neu5Ac and S100A1 levels and the condition and prognosis of cases with acute cardiogenic cerebral embolism
Objective To investigate the relationship between serum N-acetylneuramic acid(Neu5Ac)and S100 calcium-binding protein A1(S100A1)and the condition and prognosis of cases with acute cardiogenic cerebral embolism(ACCE).Methods A total of 165 cases with ACCE admitted to Chengde Cen-tral Hospital from September 2021 to September 2023 were selected.For this study,the cases were divided into two groups based on infarction size:a small/medium area group(97 cases with infarction diameter≤4 cm)and a large area group(68 cases with infarction diameter>4 cm).Additionally,based on NIHSS score,108 cases were categorized into a low NIHSS group(NIHSS<16)and 57 cases into a high NIHSS group(NIHSS≥16).The levels of Neu5Ac and S100A1 in the ACCE cases were measured.After 3 months'post-discharge,the cases were further divided into a poor prognosis group(n=41)and a good prognosis group(n=124)based on their mRS scores.Pearson correlation was used to investigate the relationship between serum Neu5Ac,S100A1,in-farct size,and NIHSS score.Prognostic factors were evaluated using multivariate logistic regression.Results Serum levels of Neu5Ac and S100A1 in the small/medium area group were lower than those in the large area group(P<0.05).The serum levels of Neu5Ac and S100A1 in the low NIHSS group were lower than those in the high NIHSS group(P<0.05).Serum Neu5Ac and S100A1 were positively correlated with cerebral infarction size and NIHSS score(P<0.001).The serum Neu5Ac and S100A1 levels in cases with ACCE in the good prog-nosis group were lower compared to the poor prognosis group(P<0.05).The proportion of large infarct area and NIHSS score in the good prognosis group were also lower compared to the poor prognosis group(P<0.05).The large infarct size,NIHSS score at admission≥15.33,Neu5Ac≥274.58 ng/mL,and S100A1≥5.08 ng/mL were identified as risk factors for poor prognosis in cases with ACCE(P<0.05).Conclusion Serum Neu5Ac and S100A1 are associated with the size of cerebral infarction and NIHSS score in patients with ACCE.They may be used as potential markers to predict the disease and prognosis of patients.
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