Efficacy of Biantongling Capsule in the treatment of patients with constipation after stroke and its effect on serum IL-1β,IL-6,TNF-α and intestinal flora levels
Objective To observe the curative effect of Biantongling capsule and its influences on levels of serum interleukin 1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and intestinal floras in patients with constipation after cerebral vascular accident(CVA).Methods A total of 90 patients with constipation after CVA who were treated at our hospital from May 2021 to May 2023 were selected.They were divided into three groups:Biantongling group,probiotics group and lactulose group using a random num-ber table method,each containing 30 cases.The total effective rate after treatment,NIHSS score before and af-ter treatment,changes in intestinal flora,serum inflammatory factors,CCK-8 levels and incidence of adverse reactions after intervention were compared among the three groups.Results After treatment,the total effective rate of treatment in the Biantongling group was higher than that in the probiotic group and the lactulose group,and the difference was statistically significant(x2=6.540;P<0.05).After treatment,the NIHSS score of neuro-logical function and the levels of serum IL-1β,IL-6,and TNF-α in the Biantongling group were lower than those in the probiotics group and the lactulose group,and the differences were statistically significant(F=176.026,12.574,17.451,5.143,P<0.05).After treatment,the level of CKK-8 in the Biantongling group was higher than that in the probiotics group and the lactulose group,and the difference was statistically significant(F=6.422,P<0.05).After treatment,the levels of bifidobacteria and lactobacilli in the Bibian Tongling group were higher than those in the lactulose group,and the differences were statistically significant(F=25.327,4.716,P<0.05).The levels of Escherichia coli and Enterococcus were lower than those in the probiotics group and the lactulose group,and the differences were statistically significant(F=36.966,28.806,P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups during treatment(x2=0.310,P>0.05).Conclusion Compared to probiotics and lactulose,Biantongling capsule can enhance the effi-cacy of patients with constipation after CVA,improve neurological function,effectively inhibit inflammatory response,regulate intestinal flora,and has a high level of safety.
Biantongling capsuleConstipation after cerebral vascular accidentCurative effectInflammatory factorIntestinal flora
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