Expression and clinical significance of CK7,TTF-1 and Ki-67 in lung adenocarcinoma
Objective To investigate the expression and clinical significance of cytokeratin 7(CK7),thyroid transcription factor 1(TTF-1)and recombinant Ki-67(Ki-67)in lung adenocarcinoma.Meth-ods A total of 131 patients with lung adenocarcinoma who were admitted to the People's Hospital of Daxing District,in Beijing from April 2020 to January 2023 were selected as study subjects.The objectives of the study were to compare the expression of CK7,TTF-1 and Ki-67 in lung adenocarcinoma tissues with that in paracan-cerous tissues,analyze the relationship between pathological features and the expression of CK7,TTF-1,and Ki-67 in patients with lung adenocarcinoma,assess the diagnostic efficacy of CK7,TTF-1,and Ki-67 alone and in combination for lung adenocarcinoma,and evaluate the consistency of the diagnostics of lung adenocarci-noma using the analysis of CK7,TTF-1,and Ki-67 alone and in combination.The consistency of CK7,TTF-1,and Ki-67 alone and in combination was analyzed.Results The positive rates of CK7,TTF-1,and Ki-67 ex-pression in lung adenocarcinoma tissues were significantly higher than that in paracancerous tissues,and the dif-ference was statistically significant(P<0.05).There was no significant difference in the positive expression rates of CK7,TTF-1,and Ki-67 among different stages,tumor diameters and differentiation degrees of lung adeno-carcinoma(P>0.05).The positive expression rates of CK7,TTF-1,and Ki-67 with lymph node metastasis were higher than those without lymph node metastasis,and the difference was statistically significant(P<0.05).The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of the combined de-tection of lung adenocarcinoma by CK7,TTF-1,and Ki-67 were higher than those of CK7,TTF-1,and Ki-67 alone(P<0.05).The concordance Kappa values for the diagnosis of lung adenocarcinoma and the pathological findings by CK7,TTF-1,and Ki-67 alone and in combination were 0.734,0.763,0.719,and 0.935,respectively.Conclusion CK7,TTF-1,and Ki-67 are highly expressed in lung adenocarcinoma tissues.The three indicators can assist in the diagnosis of lung adenocarcinoma and provide a reliable basis for clinical diagnosis of the disease.
NETL
NSTL
万方数据
