Prognostic value of D-dimer and C-reactive protein/prealbumin ratio in patients with craniocerebral trauma
Objective To investigate the prognostic value of D-dimer and C-reactive protein/preal-bumin(CRP/PA)ratio in patients with craniocerebral trauma.Methods A total of 100 patients with cranioce-rebral trauma treated at Suzhou High-tech District People's Hospital from January 2019 to August 2023 were ret-rospectively selected and divided into a poor prognosis group(32 cases)and a good prognosis group(68 cases)based on their prognosis at a 3-month post-operation follow-up.Clinical data,D-dimer levels and CRP/PA lev-els of the two groups were compared.A multivariate logistic regression model was used to analyze the factors af-fecting the prognosis of patients with craniocerebral trauma,and a receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of D-dimer and CRP/PA levels on the prognosis of these pa-tients with craniocerebral trauma.Results Compared to the group with a good prognosis,the group with a poor prognosis had a higher proportion of injuries with treatment times≥6 hours and a higher the proportion of cerebral hernia formation,withstatistically significant differences(x2=7.448,6.553,P<0.05).Additionally,the poor prognosis group had higher levels of D-D,CRP,and CRP/PA,and lower levels of PA compared to the good prognosis group,with statistical significance(t=6.795,5.008,6.945,13.829,P<0.05).Multivariate lo-gistic regression analysis showed that the proportion of patients with≥6 hours,formation of cerebral hernia,high levels of D-D,CRP,CRP/PA,and low levels of PA were all risk factors for a poor prognosis in patients with craniocerebral trauma(P<0.05).The ROC curve showed that the area under the curve(AUC)for D-di-mer,CRP/PA,and their combination in predicting the prognosis of patients with craniocerebral trauma were 0.830,0.853 and 0.914,respectively.Conclusion Both D-dimer and CRP/PA levels can predict the prognosis of patients with craniocerebral trauma.When used in combination,they provide a more accurate prediction.
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