Analysis of pathogenic bacteria characteristics,myocardial enzyme profile and disease outcome factors in patients with infective endocarditis
Objective To investigate the characteristics of pathogenic bacteria,the level of myocar-dial enzymes and the outcome factors of infectious endocarditis(IE).Methods 102 IE patients admitted to Qilu Hospital of Shandong University from March 2021 to December 2023 were selected.Based on the blood culture results,they were divided into two groups:negative group(31 cases),and positive group(71 cases).According to whether the patients died during hospitalization,they were divided into the death group(9 cases)and the sur-vival group(93 cases).The distribution characteristics of pathogenic bacteria in IE patients were analyzed,and the changes of serum inflammatory index and myocardial enzyme spectrum index between the negative group and positive group were compared.The correlation between the level of myocardial enzyme spectrum and inflamma-tion index in IE patients were explored by Pearson correlation analysis.The prognostic factors of IE patients were explored by Binary logistic stepwise regression.Results The positive blood culture rate in 102 IE patients was 69.61%(71/102).Tumor necrosis factor-α(TNF-α),interleukin-2(IL-2),interleukin-6(IL-6),creatine ki-nase isoenzyme(CK-MB),creatine kinase(CK)and lactate dehydrogenase(LDH)levels in the positive group were higher than those in the negative group,with statistical significance(P<0.05).Pearson correlation analysis showed that the serum levels of CK-MB,CK,and LDH in IE patients were positively correlated with TNF-α,IL-2,and IL-6(P<0.05).The proportion of age≥60 years in death group,the proportion of diabetes history,the proportion of cardiac function grade Ⅲ to Ⅳ,the proportion of cardiac neoplasma size≥15 mm,the proportion receiving surgical treatment,the level of TNF-α,IL-2,IL-6,CK-MB,CK,and LDH were higher than those in the survival group,and the hemoglobin level was lower than that in the survival group,with statistical significance(P<0.05).Multivariate regression analysis showed that the size of cardiac neo-plasms≥15 mm,low hemoglobin levels,high CK-MB levels,high CK levels and high LDH levels were inde-pendent risk factors for prognosis in IE patients(P<0.05).Conclusion The main pathogens in IE patients are gram-positive bacteria.The severity of the disease can be determined by monitoring the levels of myocardial en-zymes.The size of cardiac neoplasms,hemoglobin and myocardial enzyme profile are all factors related to the prognosis of IE patients.
IEPathogenic bacteriaMyocardial enzyme profileIndicators of inflammation
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