Correlation between serum miR-29a level and microangiopathy in diabetic nephropathy patients
Objective To investigate the correlation between serum miR-29a level and microangi-opathy in diabetic nephropathy(DN)patients.Methods A total of 204 patients with DN admitted to Henan Pingmei What Medical Group General Hospital were selected as the observation group,and 204 healthy subjects were selected as the control group during the same period.General data and miR-29a levels were compared be-tween the two groups.According to the urinary protein excretion rate(UAER)level,DN patients were divided into clinical albuminuria(microangiopaopathy)group(69 cases),microalbuminuria group(86 cases)and nor-mal albuminuria group(49 cases).General data and miR-29a levels were compared,and the correlation be-tween miR-29a and indicators with statistical difference of single factor was analyzed in the observation group.Logistic regression was used to analyze the influencing factors of microangiopathy.ROC curve analysis was used to evaluate the clinical value of miR-29a in the assessment of microvascular diseases.Results Compared to the control group,the observation group had higher levels of systolic blood pressure,diastolic blood pres-sure,fasting blood glucose,glycated hemoglobin,total cholesterol,triglycerides,uric acid,serum creatinine,cystatin C and miR-29a.Conversely,the levels of low-density lipoprotein and glomerular filtration rate were lower(t=9.475,6.296,35.083,39.770,9.548,6.073,44.190,22.329,28.088,14.560,14.479,8.600,P<0.05).When comparing the disease course,fasting blood glucose,cystatin C and miR-29a levels among differ-ent urinary protein groups,it was found that the clinical albuminuria group>microalbuminuria group>normal albuminuria group.When comparing the levels of low-density lipoprotein and glomerular filtration rate:the clinical albuminuria group<microalbuminuria group<normal albuminuria group(F=45.678,49.246,43.017,122.661,64.022,66.978,P<0.05).Correlation analysis showed that miR-29a was positively correlated with the disease course,fasting blood glucose,low-density lipoprotein and cystatin C levels,but negatively corre-lated with glomerular filtration rate(r=0.447、0.346、0.423、0.572、-0.559,P<0.05).Logistic regression analy-sis showed that glomerular filtration rate,cystatin C and miR-29a were independent risk factors for microangi-opathy.The ROC curve analysis results showed that when the cut-off value of miR-29a was 30.65,the AUC for evaluating patients with microangiopathy was 0.89.Conclusion The increased levels of miR-29a in DN pa-tients are closely related to the severity of their disease.This bopmarker can serve as an additional indicator to as-sess microangiopathy in DN patients.
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