Influence of transversus abdominis plane block on serum S-100β,NSE and oxidative stress in patients with laparoscopic cholecystectomy
Objective To explore the influence of transversus abdominis plane block on serum cen-tral nervous specific protein(S-100β),neuron specific enolase(NSE)and oxidative stress in patients undergo-ing laparoscopic cholecystectomy.Methods 130 patients undergoing laparoscopic cholecystectomy at Wuwei City People's Hospital were enrolled as the research subjects from June 2020 to January 2023.Using a simple randomization method,they were divided into an observation group and a control group with 65 cases in each group.The control group received conventional intubation anesthesia before surgery,while the observation group received transversus abdominis plane block anesthesia based on the control group.Changes in serum S-100β,NSE,oxidative stress indicators[cortisol(Cor),epinephrine]and inflammatory mediators[serum C-re-active protein(CRP),interleukin-6(IL-6),interleukin-2(IL-2)]were compared before and after surgery.Re-covery time,postoperative pain levels and incidence rates of adverse symptoms were recorded.Results The levels of serum S-100β,NSE,Cor and epinephrine in the observation group after surgery were lower than those in the control group(P<0.05).The levels of inflammatory factors of CRP,IL-6,and IL-2 were significantly lower in the observation group(P<0.05).The VAS score and incidence rates of adverse symptoms in the obser-vation group after surgery were significantly lower compared to the control group,and the recovery time was significantly shorter than that in the control group(P<0.05).Conclusion The transversus abdominis plane block has a significant effect on patients undergoing laparoscopic cholecystectomy,and it can effectively allevi-ate inflammatory injury and stress response.
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