Correlation of serum IL-6,KLF2,and SP-D with the severity and prognosis of neonatal acute respiratory distress syndrome
Objective To explore the correlation between serum interleukin-6(IL-6),Kruppel-like transcription factor 2(KLF2),serum pulmonary surfactant protein D(SP-D),and the severity and prognosis of neonatal acute respiratory distress syndrome(ARDS).Methods A total of 224 children with ARDS were admitted to Tongzhou District Maternal and Child Health Hospital from January 2022 to June 2023 and were retrospectively selected.Based on their oxygen index,the ARDS group was divided into three categories:mild group(87 cases),moderate group(74 cases)and severe group(63 cases).Additionally,based on prognosis,the ARDS group was divided into two groups:a good prognosis group(145 cases)and a poor prognosis group(79 cases).The serum levels of IL-6,KLF2,and SP-D were compared among children with different severity of the disease.Theaim was to analyze the correlation between serum IL-6,KLF2,SP-D levels,and oxygen index and the prognostic value of ARDS children.Results Serum IL-6 and SP-D levels increased gradually,while KLF2 levels decreased with the worsening of ARDS,showing statistical significance(F=155.041,56.005,198.070,P<0.05).Serum IL-6 and SP-D levels were higher in the poor prognosis group than those in the good prognosis group,and KLF2 levels were lower than those in the good prognosis group,with statistical significance(t=8.681,8.038,7.823,P<0.05).The severity of ARDS in children was positively correlated with serum IL-6 and SP-D levels(r=0.823,0.786,P<0.05),and negatively correlated with KLF2 level(r=-0.761,P<0.05).Results from ROC curve analysis indicated that the areas under the curve for the three independent and combined detection to predict the prognosis of ARDS children were:0.806,0.794,0.767 and 0.914,respectively,which weresuperior to individual tests(P<0.05).Conclusion Serum IL-6,KLF2 and SP-D levels are closely related to the severity of neonatal acute respiratory distress syndrome,and have prognostic value for children with ARDS.The combined detection of these three factors has higher predictive efficiency.
Acute respiratory distress syndromeNewbornPulmonary surfactant protein DInter-leukin-6Kruppel-like transcription factor 2
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NSTL
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