Correlation between serum NQO1,CRP/ApoA1,sRAGE and coronary artery disease in patients with essential hypertension
Objective To investigate the correlation between serum quinone oxidoreductase(NQO1),C-reactive protein to apolipoprotein A1 ratio(CRP/ApoA1)and soluble advanced glycation end-product receptor(sRAGE)and coronary artery disease in patients with essential hypertension.Methods The data of 122 patients with essential hypertension from the First Affiliated Hospital of Guangdong Pharmaceutical University from June 2021 to December 2022 were retrospectively analyzed.Patients with coronary artery dis-ease were divided into two groups:the simple hypertension group(77 cases)and the coronary artery disease group(45 cases)based on whether they were complicated with coronary artery disease.Within the coronary ar-tery disease group,patients were further divided into mild(14 cases),moderate(18 cases)and severe group(13 cases)groups according to the Gensini score.Serum levels of NQO1,CRP/ApoA1,and sRAGE were com-pared between the two groups.The correlations between NQO1,CRP/ApoA1,sRAGE,and Gensini scores were analyzed using the Pearson correlation test.A multivariate logistic regression model was used to analyze the influencing factors of coronary artery disease in hypertensive patients.Results Compared to the simple hy-pertension group,the proportion of smoking and diabetes in the pathological change group was significantly higher(x2=22.215,9.872,P<0.05).The duration of hypertension,systolic blood pressure,diastolic blood pres-sure,serum CRP,and CRP/ApoA1 in the lesion group were higher than those in the simple hypertension group significantly(t=7.539,6.192,10.923,24.049,17.362,P<0.05),while the NQO1 and sRAGE in the lesion group were significantly lower(t=11.530,6.746,P<0.05).Pearson analysis showed that serum NQO1 and sRAGE were negatively correlated with the Gensini score(P<0.001),while CRP/ApoA1 was positively corre-lated with the Gensini score(P<0.001).Multivariate logistic regression analysis showed that systolic blood pres-sure,diastolic blood pressure,diabetes history,serum CRP,ApoA1,NQO1,CRP/ApoA1,and sRAGE were all influential factors for complicated coronary artery disease(P<0.05).Conclusion In patients with essential hypertension complicated by coronary artery disease,serum NQO1 and sRAGE show a negative correlation with the severity of lesions.Conversely,CRP/ApoA1 demonstrates a positive correlation with the lesion sever-ity,suggesting it can be used as a predictor of coronary artery disease in hypertension patients.
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