Relationship between peripheral blood NLRP3 inflammasome,serum IL-1β,IL-18 levels and type 2 diabetes mellitus with chronic periodontitis
Objective To investigate the relationship between NOD-like receptor pyrin domain containing 3(NLRP3)inflammasome in peripheral blood,serum interleukin-1β(IL-1β),interleukin-18(IL-18)levels and type 2 diabetes mellitus(T2DM)with chronic periodontitis.Methods The clinical data of 60 patients with T2DM complicated by chronic periodontitis admitted to Shijiazhuang Second Hospital from March 2022 to February 2023 were retrospectively analyzed.These patients were designated as the treatment group.60 healthy people who went through physical examinations at our hospital were randomly selected as the control group.The control group did not receive any treatment,while the observation group underwent erbium laser therapy combined with basic periodontal treatment.The levels of NLRP3 inflammasome,IL-1β,and IL-18 be-tween the two groups before treatment were analyzed.In the treatment group,changes in serum inflammation levels(NLRP3 inflammasome,IL-1β,IL-18),blood glucoselevels,and periodontal conditions were compared before treatment and after 1 week,2 weeks,and 4 weeks of treatment.The Pearson method was used to analyze the correlation between NLRP3 inflammasome level and IL-1β,IL-18,FPG,PBG,PD,PLI,AL,BI after 4 weeks of treatment.Results The levels of NLRP3 inflammasome,IL-1β,and IL-18 in the treatment group were higher than those in the control group(P<0.05).After treatment,NLRP3 inflammasome,IL-1β,IL-18,PD,PLI,AL,and BI in the treatment group were lower than before treatment,and the levels decreased with treatment time(P<0.05).After treatment,there were no statistical differences in FPG and PBG in the treatment group compared with before treatment(P>0.05).Pearson method analysis showed that the level of NLRP3 in-flammasome was positively correlated with IL-1β,IL-18,FPG,PBG,PD,PLI,AL,and BI(P<0.05).Con-clusion The levels of NLRP3 inflammasome,IL-1β,and IL-18 in T2DM patients with chronic periodontitis were found to be abnormally elevated.The NLRP3 pathway may play a role in promoting the pathogenesis of chronic periodontitis in patients with T2DM.
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