Clinical significance of PCT,IGF-1 and HBP in serum and cerebrospinal fluid in neonates with purulent meningitis induced by GBS infection
Objective To explore the expression levels and clinical significance of procalcitonin(PCT),insulin-like growth factor(IGF)-1 and heparin-binding protein(HBP)in serum and cerebrospinal fluid in neonates with purulent meningitis(PM)induced by group B streptococcus(GBS)infection.Methods A to-tal of 44 neonates with PM induced by GBS infection and 44 neonates with suspected PM in the hospital were en-rolled as the PM group and the control group between May 2019 and May 2023,respectively.The expression levels of PCT,IGF-1 and HBP in serum and cerebrospinal fluid were detected and compared between the two groups,and differences in neonates with varying disease severity were observed.After treatment,the prognosis of PM neonates was evaluated.The prognostic value of the three indexes was analyzed using ROC curves.Results The levels of serum PCT and HBP in the PM group were higher than those in the control group,while IGF-1 was lower than in the control group,and levels of PCT,HBP and IGF-1 in cerebrospinal fluid were higher in the PM group compared to the control group(P<0.05).The levels of serum PCT and HBP in neonates with severe PM were higher than those with mild PM,while IGF-1 was lower than that with mild PM,and lev-els of PCT,IGF-1 and HBP in cerebrospinal fluid were all higher than those with mild PM(P<0.05).Among the 44 PM neonates,the incidence of poor prognosis was 27.27%.The levels of serum PCT and HBP in neo-nates with poor prognosis were higher than those with good prognosis,IGF-1 was lower than that with good prognosis,and levels of PCT,IGF-1 and HBP in cerebrospinal fluid were all higher than those with good prog-nosis(P<0.05).ROC curve analysis showed that PCT,IGF-1 and HBP in both serum and cerebrospinal fluid were prognostic indicators(P<0.05).There was no significant difference in AUC between the combined serum indicators and combined cerebrospinal fluid indicators(P>0.05).Conclusion The changes of PCT,IGF-1 and HBP in serum and cerebrospinal fluid are correlated with disease severity and prognosis.These changes can help evaluate and predict the severity and prognosis of neonates with PM induced by GBS infection.
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