Study on predictive factors of hemorrhagic transformation in intravenous thrombolysis in acute ischemic stroke
Objective To study the predictive factors for hemorrhagic transformation in acute isch-emic stroke patients undergoing intravenous thrombolysis.Methods A total of 114 patients with acute isch-emic stroke treated with intravenous thrombolysis in the Neurology Department of the Affiliated Chuzhou Hos-pital of Anhui Medical University(Chuzhou First People's Hospital)from January 2020 to September 2023 were selected as the research subjects.They were divided into observation group(HT,12 cases)and control group(no HT,102 cases)according to whether bleeding transformation occurred.The general and clinical data of the two groups of patients were compared,variables with statistically significant differences were in-cluded in the multifactor analysis affecting hemorrhagic transformation in acute ischemic stroke,the efficacy of predictive factors was tested using the Receiver Operating Characteristic(ROC)curve.Results There were significant differences in NIHSS score,age,and preoperative antiplatelet therapy proportion between the ob-servation group and the control group(P<0.05).Multifactor Logistic regression analysis showed a significant positive correlation between NIHSS score and hemorrhagic transformation in acute ischemic stroke treated with intravenous thrombolysis(OR=1.140,P<0.05).The area under ROC curve of NIHSS score predicted HT was 0.79,with a sensitivity of 83%,specificity of 64%,and Youden index of 0.47.Conclusion NIHSS score may be an independent predictive factor for hemorrhagic transformation in acute ischemic stroke patients under-going intravenous thrombolysis.
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