Curative effect of penehyclidine hydrochloride combined with pralidoxime chloride and its influences on renal function,serum PCT,CHE and CRP in patients with acute severe organophosphorus pesticides poisoning
Objective To explore the curative effect of penehyclidine hydrochloride combined with pralidoxime chloride and its influences on renal function,serum procalcitonin(PCT),cholinesterase(CHE)and C-reactive protein(CRP)in patients with acute severe organophosphorus pesticides poisoning(ASOPP).Methods According to the random number table method,100 patients with ASOPP were admitted to Taihe Hospital Affiliated with Wannan Medical College and were divided into an observation group(n=50)and a control group(n=50)between January 2018 and January 2023.The control group received routine treat-ment along with pralidoxime chloride,while the observation group received treatment with penehyclidine hydro-chloride in addition to pralidoxime chloride.The effectiveness of the treatment was compared between the two groups.Results After treatment,the recovery time of CHE and hospitalization time in the observation group were shorter than those in the control group.The cure rate was also higher in the observation group compared to the control group,and the difference was statistically significant(P<0.05).After treatment,levels of serum cre-atinine(Scr),β2-microglobulin(β2-MG),cystatin C(Cys-C),PCT,and CRP in the observation group were lower than those in control group.Conversely,CHE levels were higher in the observation group compared to the control group,with a statistically significant difference(P<0.05).There was no significant difference in the oc-currence of adverse reactions between the two groups(P>0.05).Conclusion Penehyclidine hydrochloride,when combined with pralidoxime chloride,can increase the activity of serum CHE,shorten treatment time,im-prove renal function,and reduce levels of serum PCT and CRP in ASOPP patients.These effects are achieved without increasing adverse reactions.
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