Expression of NT-proBNP,TSP-2,and hs-CRP in patients with non-valvular HFrEF and their predictive value for short-term prognosis
Objective To investigate the expression of N-terminal brain natriuretic peptide precur-sor(NT-proBNP),platelet adsorbed protein 2(TSP-2),and ultrasensitive C-reactive protein(hs-CRP)in pa-tients with nonvalvular heart failure with reduced ejection fraction(HFrEF)and their predictive value for short-term prognosis.Methods One hundred and twenty non-valvular HFrEF patients admitted to the First Affiliated Hospital of Zhengzhou University from January 2018 to December 2021 were selected as the HFrEF group,60 non-valvular ejection fraction-preserved heart failure(HFpEF)patients were selected as the HFpEF group,and 60 patients with normal cardiac function in heart failure(HF)were selected as the control group.The NT-proBNP,TSP-2,and hs-CRP levels of patients in the three groups were tested and compared respectively.Pa-tients in the HFrEF group were divided into cardiac function class Ⅱ,cardiac function class Ⅲ,and cardiac func-tion class Ⅳ groups based on cardiac function classification,and the NT-proBNP,TSP-2,and hs-CRP levels of patients in the three groups were compared.The correlation between the NT-proBNP,TSP-2,and hs-CRP indi-cators was analyzed.The correlation between the NT-proBNP,TSP-2,and hs-CRP indicators was determined according to follow-up.The correlation between the NT-proBNP,TSP-2,and hs-CRP indicators was deter-mined according to follow-up.The multifactorial factors affecting the prognosis of HFrEF patients,and the short-term prognostic predictive value of NT-proBNP and TSP-2 for HFrEF patients were analyzed.Results The levels of NT-proBNP,TSP-2 and hs-CRP in the three groups were HFrEF group>HFpEF group>control group,and the difference was statistically significant(P<0.05).Among the 120 patients with non-valvular HFrEF,38 cases(31.67％)were in cardiac class Ⅱ,46 cases(38.33％)were in cardiac class Ⅲ,and 36 cases(30.00％)were in cardiac class Ⅳ(P<0.05).The levels of NT-proBNP,TSP-2 and hs-CRP in the three groups were in cardiac class Ⅳ group>cardiac class Ⅲ group>cardiac class Ⅱ group,and the difference was statistically significant(P<0.05).Serum NT-proBNP was positively correlated with TSP-2 and hs-CRP in patients with non-valvular HFrEF(P<0.05).Out of 120 cases of non-valvular HFrEF patients,79 cases(65.83％)had a good prognosis and 41 cases(34.17％)had a poor prognosis.The levels of NT-proBNP,TSP-2,and hs-CRP in the patients were in the poor prognosis group>good prognosis group,and the difference was statistically significant(P<0.05).The results of logistic regression analysis showed that high expression of NT-proBNP,TSP-2,and hs-CRP was the main cause of non-valvular HFrEF.High CRP expression was a risk factor for poor prognosis in pa-tients with non-valvular HFrEF(P<0.05).The AUCs of NT-proBNP,TSP-2,and hs-CRP alone and in combi-nation for predicting prognosis in patients with nonvalvular HFrEF were 0.779,0.907,0.898,and 0.948,re-spectively,with the combined prediction being higher than that of NT-proBNP,TSP-2 and hs-CRP alone(P<0.05).Conclusion NT-proBNP,TSP-2 and hs-CRP are highly expressed in patients with non-valvular HFrEF.The combination of these biomarkers can better predict the short-term prognosis of patients.
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