Levels and clinical significance of serum ox-LDL and sdLDL-C in patients with transient ischemic attack
Objective To explore the levels and clinical significance of serum oxidized low density lipoprotein(ox-LDL)and small dense low density lipoprotein cholesterol(sdLDL-C)in patients with transient ischemic attack(TIA).Methods 216 patients with TIA at Yan'an University Affiliated Hospital from April 2021 to September 2022 were enrolled in the observation group.Based on the ABCD-3 score,the patients in the observation group were classified into the low-risk group(n=77),the middle-risk group(n=93)and the high-risk group(n=46).150 healthy subjects who underwent physical examinations during the same period were se-lected as the control group.The levels of serum ox-LDL and sdLDL-C were compared between the two groups and among patients with different ABCD-3 scores in the observation group.Pearson correlation coefficient was used to analyze the correlation between serum ox-LDL and sdLDL-C levels and ABCD-3 score.The patients in the observation group were followed up for 1 year after disease onset and were divided into the AIS group(n=43)and the non-AIS group(n=173)based on the presence or absence of acute ischemic stroke(AIS).Serum levels of ox-LDL and sdLDL-C were compared.Receiver operating curve was applied to analyze the predictive value of serum ox-LDL and sdLDL-C levels on progression of TIA patients to AIS.Results Serum levels of ox-LDL and sdLDL-C in the observation group were significantly higher than those in the control group(P<0.05).The levels of serum ox-LDL and sdLDL-C were manifested as low-risk group<middle-risk group<high-risk group(P<0.05).Pearson correlation coefficient analysis showed that the levels of serum ox-LDL and sdLDL-C in patients with TIA were significantly positively correlated with the ABCD-3 score(P<0.05).The lev-els of serum ox-LDL and sdLDL-C were significantly higher in the AIS group than in the non-AIS group(P<0.05).ROC curve analysis revealed that the sensitivities of serum ox-LDL and sdLDL-C levels alone and in com-bination to predict the progression of TIA patients to AIS were 0.791,0.814 and 0.954,respectively.The speci-ficities were 0.751,0.636 and 0.624,and the AUCs were 0.789,0.792 and 0.872 respectively.Conclusion The levels of serum ox-LDL and sdLDL-C in TIA patients are highly expressed,and are strongly correlated with the disease condition.Both indicators have a high predictive value for the progression of TIA to AIS patients.
NETL
NSTL
万方数据
