Evaluation value of serum CYR61,IL-17 and Klotho protein in patients with Graves eye disease
Objective To evaluate the value of serum homocysteine protein 61(CYR61),interleu-kin-17(IL-17)and unidirectional transmembrane protein(Klotho)in Graves ophthalmopathy(GO).Meth-ods The clinical data of 103 patients treated in Department 5 of Ophthalmology at the First Affiliated Hospital of Zhengzhou University from January 2020 to October 2023 were retrospectively collected as the study sub-jects.The condition of 103 patients was evaluated based on their clinical activity score(CAS),and they were di-vided into the active group(42 cases)and the inactive group(61 cases).The general data and clinical basic indi-cators(tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),thyrotropin(TSH),free triiodothyronine(FT3),free thyroxine(FT4)and TSH)of the two groups were compared.The levels of receptor antibody(TRAb),CYR61,IL-17,Klotho protein and CAS score were analyzed,and the related influencing factors and predictive value of GO eye disease activity were analyzed by multivariate regression analysis and ROC curve.Results Klotho,TSH,FT3,FT4,TRAb,TNF alpha,IFN-gamma,CYR61 levels,and CAS score of the ac-tive group were higher than those of the inactive group,the difference was statistically significant(t=7.953,4.364,5.232,6.100,4.364,7.344,4.890,6.541,6.995,13.283,P<0.05).Multivariate regression analysis showed that TSH,FT3,FT4,TRAb,TNF-α,IFN-γ,IL-17,Klotho,CYR61 combined with CAS score were independent risk factors affecting the active stage of GO eye disease(OR=1.730,1.667,1.689,1.692,1.742,1.791,1.863,1.887,1.828,1.842,P<0.05).The combined predictive value of CYR61,IL-17,and Klotho for GO activity was higher than that of the three individual tests,and the area under the curve(AUC)was 0.943,0.827,0.817 and 0.866,respectively(P<0.05).Conclusion Serum CYR61,IL-17 and Klotho proteins are closely related to the stage of GO activity.The combined detection of the three proteins is effective in predicting GO disease,with an accurate evaluation value.
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