Expression of miR-203 and CREB1 in patients with multiple myeloma and their relationship with prognosis
Objective To study the expression of microRNA-203(miR-203)and cyclic adenosine monophosphate response element binding protein 1(CREB1)in multiple myeloma patients and their relation-ship with prognosis.Methods A total of 182 patients with multiple myeloma admitted to the Fifth Affiliated Hospital of Zhengzhou University from June 2017 to June 2020 were retrospectively selected as the research sub-jects.The expression levels of miR-203 and CREB1 mRNA in patients with multiple myeloma and normal tis-sues were detected using fluorescence quantitative polymerase chain reaction.The patients were followed up for 3 years after treatment.Kaplan-Meier life curve was used for survival analysis,and cox regression analysis was used to analyze the prognostic factors.Results The expression of miR-203 in multiple myeloma tissues was lower than that in normal tissues,while the expression of CREB1 mRNA was higher than that in normal tissues(t=29.412,49.955,P<0.05).Cox regression analysis showed that ISS stage,miR-203 expression and CREB1 mRNA expression were risk factors for progression-free survival and overall survival of multiple myeloma pa-tients(P<0.05).Kaplan-Meier life curve analysis showed that progression-free survival and overall survival in patients with high miR-203 expression were higher than those with low miR-203 expression(P<0.05).The pro-gression-free survival rate and overall survival rate of patients with low CREB1 mRNA expression were higher than those with high CREB1 mRNA expression(P<0.05).Conclusion The expression level of miR-203 de-creased,while CREB1mRNA increased in patients with multiple myeloma.Both of these factors are related to the prognosis of patients with multiple myeloma.
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