Value of serum miR-34a,IL-1β and TNF-α combined detection in patients with irretrievable pulpitis
Objective To evaluate the prognostic value of serum microRNA-34A(miR-34a),interleukin-1β(IL-1β)and tumor necrosis factor α(TNF-α)in patients with irreversible pulpitis.Methods 88 patients with irreversible pulpitis admitted to Huainan First People's Hospital from January 2019 to June 2023 were selected as the study subjects and referred to as the case group(n=88),and 60 healthy individuals who underwent physical examinations at our hospital during the same period were chosen as the control group(n=60).Serum levels of miR-34a,IL-1β,and TNF-α were compared between the two groups.Patients in the case group received conventional treatment,and were divided into the good prognosis group(n=67)and the poor prognosis group(n=21)based on follow-up results three months after the end of treatment.Multivariate logistic regression was used to analyze the influencing factors of poor prognosis in patients with irreversible pulpitis after conventional treatment,an ROC curve was drawn to analyze the predictive value of serum miR-34a,IL-1β,and TNF-α levels for poor prognosis in patients with irreversible pulpitis after conventional treatment.Results The serum levels of miR-34a,IL-1β,and TNF-α in the case group were higher than those in the control group,and the differences were statistically significant(t=14.715,18.881,21.318,P<0.05).Multivariate logistic regression analysis showed that no crown repair,soft texture of detrus,light yellow/yellow color of detrus,high expression of serum miR-34a,elevated IL-1β level and elevated TNF-α level were all irreversible independent risk factors for the poor prognosis of patients with pulpitis after conventional treatment(P<0.05).ROC curve analysis showed that the levels of serum miR-34a,IL-1β,and TNF-α and the AUC of combined detection were 0.873,0.805,0.780 and 0.947,respectively.Combined detection was superior to single detection(P<0.05).Conclusion The expression levels of serum miR-34a,IL-1β,and TNF-α are increased in patients with irreversible pulpitis.The combined detection may serve as an auxiliary indicator to evaluate the poor prognosis of treatment.
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