分子诊断与治疗杂志2024,Vol.16Issue(7) :1191-1194,1199.

非编码RNA与人巨细胞病毒潜伏感染关系的研究进展

Research progress on the relationship between non-coding RNA and latent infection of human cytomegalovirus

周晋宇 张倩 沈茹 郭举鼎 解天绒 舒丽丽 朱昱
分子诊断与治疗杂志2024,Vol.16Issue(7) :1191-1194,1199.

非编码RNA与人巨细胞病毒潜伏感染关系的研究进展

Research progress on the relationship between non-coding RNA and latent infection of human cytomegalovirus

周晋宇 1张倩 1沈茹 1郭举鼎 1解天绒 1舒丽丽 1朱昱1
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作者信息

  • 1. 昆明市妇幼保健院检验科,云南,昆明 650506
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摘要

人巨细胞病毒(HCMV)是一种高宿主特异性疱疹病毒,其感染率高、潜伏感染激活后的致病性强.由于目前尚无针对病毒潜伏感染的监测手段,导致HCMV临床诊断困难.近年来有研究报道非编码RNA在疱疹病毒的潜伏感染过程中发挥重要作用,提示可以将HCMV感染相关的特异性非编码RNA应用于病毒潜伏感染期的诊断和监测.本文就与HCMV潜伏感染相关的非编码RNA调控机制作简要综述,进一步阐明非编码RNA与HCMV潜伏感染的关系.

Abstract

Human cytomegalovirus (HCMV) is a ubiquitous,highly host-specific herpes virus.HCMV poses a significant challenge due to its high infection rate in the human population,strong pathogenic-ity after latent infection reactivation,and the lack of effective monitoring methods for latent infection.Recent studies have shown that non-coding RNA plays an important role in the latent infection of herpes viruses,sug-gesting that the specific expression levels of non-coding RNA can be used to assess the latent infection period of the disease.In this paper,we review the regulatory mechanisms of non-coding RNA related to HCMV latent infection to enhance our understanding.

关键词

人巨细胞病毒/潜伏感染/miRNA/lncRNA/circRNA

Key words

Human cytomegalovirus/Latent infection/miRNA/lncRNA/circRNA

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基金项目

昆明市妇幼保健院院级科研项目(2022-21)

出版年

2024
分子诊断与治疗杂志
中山大学

分子诊断与治疗杂志

CSTPCD
影响因子:0.65
ISSN:1674-6929
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